唐小芳 蒋鹏飞 陈锋

〔摘要〕 目的 探討桂枝茯苓丸联合超声引导下聚桂醇治疗盆腔囊肿的疗效。方法 选取2017年12月至2020年7月期间在益阳市中心医院行超声引导下聚桂醇硬化介入治疗的盆腔囊肿患者54例，随机分为观察组和对照组，各27例，对照组采用超声引导下聚桂醇硬化治疗，观察组在对照组基础上口服桂枝茯苓丸治疗。治疗1个月、3个月、6个月后在超声下观察囊肿最大直径，检测血清IL-6、IL-8、ICAM-1的表达，并比较两组的有效率及复发率。结果 两组治疗后各时间点的囊肿最大直径均小于治疗前（P<0.05），且观察组囊肿最大直径均小于对照组（P<0.05）;与对照组相比，观察组各时间点患者血清炎症相关因子IL-6、IL-8、ICAM-1含量均下降（P<0.05）;治疗后3个月，观察组有效率明显高于对照组（P<0.05）;随访6个月，观察组复发率明显低于对照组（P<0.05）。结论 桂枝茯苓丸联合超声引导下聚桂醇治疗盆腔囊肿能够降低复发率、提高疗效，可能与其降低血清IL-6、IL-8、ICAM-1相关，值得临床推广应用。

〔关键词〕 盆腔囊肿;桂枝茯苓丸;超声引导;聚桂醇;硬化治疗;血清炎症相关因子

〔中图分类号〕R285       〔文献标志码〕B       〔文章编号〕doi：10.3969/j.issn.1674-070X.2021.06.019

Clinical Study of Guizhi Fuling Pill Combined with Lauromacrogol Under Ultrasound

Guidance in the Treatment of Pelvic Cysts

TANG Xiaofang1， JIANG Pengfei2， CHEN Feng1*

（1. Yiyang Center Hospital of Hunan Province， Yiyang， Hunan 413000， China; 2. Hunan University of Chinese Medicine， Changsha， Hunan 410208， China）

〔Abstract〕 Objective To explore the efficacy of Guizhi Fuling Pills combined with lauromacrogol under ultrasound guidance in the treatment of pelvic cysts. Methods 54 patients with pelvic cysts who underwent ultrasound-guided interventional therapy of lauromacrogol sclerotherapy in Yiyang Central Hospital from December 2017 to July 2020 were randomly divided into observation group and control group， with 27 cases in each group， and the control group was guided by ultrasound under lauromacrogol sclerotherapy， the observation group was treated with Guizhi Fuling Pills on the basis of the control group. After treatment for 1 month， 3 months， and 6 months， the diameter of the cyst was observed under ultrasound， and the expression of serum IL-6， IL-8， ICAM-1 was detected. The effective rate and recurrence rate of the two groups were compared. Results  The maximum diameter of the cyst at each time point after treatment in the two groups was smaller than before treatment （P<0.05）， and the maximum diameter of the cyst in the observation group was smaller than the control group （P<0.05）. Compared with the control group， the serum inflammation-related factors IL-6， IL-8 and ICAM-1 levels in the observation group decreased at each time point （P<0.05）. 3 months after treatment， the effective rate of the observation group was significantly higher than that of the control group （P<0.05）; after follow-up for 6 months， the recurrence rate of the observation group was significantly lower than that of the control group （P<0.05）. Conclusion Guizhi Fuling Pills combined with ultrasound-guided lauromacrogol in the treatment of pelvic cysts has the advantages of reducing the recurrence rate and improving the curative effect， which may be related to the reduction of serum IL-6， IL-8， ICAM-1， and it is worthy of clinical application.

〔Keywords〕 pelvic cystic; Guizhi Fuling Pills; ultrasound-guided; lauromacrogol; sclerotheraphy; serum inflammation related factors

盆腔囊肿是一种常见的良性妇科疾病，较小者可无明显临床症状，较大者会压迫局部脏器，出现酸胀、疼痛等症状，治疗方式通常为手术治疗，如开腹手术、腹腔镜手术、超声引导介入等。这些手术治疗方式均有缺点，如开腹手术有创伤大、疗程长的弊端，腹腔镜手术费用高，超声引导下囊肿硬化治疗虽然有创伤小、恢复快、费用低等优势，但也存在术后囊肿复发等问题。中医药治疗盆腔囊肿有较好的疗效[1-2]，桂枝茯苓丸治疗盆腔囊肿有较久的历史[3-4]，故本研究以盆腔囊肿患者为研究对象，观察桂枝茯苓丸联合超声引导下聚桂醇治疗盆腔囊肿的疗效，总结报道如下。

1 临床资料

1.1  一般资料

选取2017年12月至2020年7月在益阳市中心医院行超声引导下聚桂醇硬化介入治疗的盆腔囊肿患者54例，按随机数字表法分为观察组与对照组，各27例。……