汤小娟　徐梦杰　朱禹诚　王元凤

摘  要： 研究了不同浓度的富硒绿茶对高盐饮食诱导下8周龄Wistar大鼠高血压的预防作用.结果表明：饮用茶水提物8周后，低、高剂量组分别降低大鼠收缩压1.20 kPa和2.80 kPa;茶水提物降低了血清中α-羟基丁酸脱氢酶和乳酸脱氢酶的含量，苏木精-伊红（HE）染色切片观察心脏、肾脏组织形态，显示低、高剂量组均可以改善大鼠心肌细胞肥大、组织紊乱，及肾小管结构损伤等问题，且高剂量组效果更加显著.可以进一步开发富硒绿茶相应的功能性食品来发挥其保健效果.

关键词： 富硒绿茶; 高盐饮食; 高血压预防

中图分类号： Q 599    文献标志码： A    文章編号： 1000-5137（2021）02-0154-08

Effect of selenium enriched green tea on hypertension induced by high salt diet of rats

TANG Xiaojuan， XU Mengjie， ZHU Yucheng， WANG Yuanfeng^*

（College of Life Sciences， Shanghai Normal University， Shanghai 200234， China）

Abstract： To study the effect of different concentrations of selenium enriched green tea on hypertension induced by high salt diet in 8-week-old Wistar rats.The results showed that：after drinking tea water extract for 8 weeks，the systolic blood pressure on rats was decreased by 1.20 kPa and 2.80 kPa at low and high doses，respectively.The contents of α-hydroxybutyrate dehydrogenase and lactate dehydrogenase in serum were decreased by tea extract.The histological morphological characteristics of heart and kidney were observed by hematoxylin eosin （HE） staining.The results showed that the low-dose and high-dose groups could improve myocardial hypertrophy，tissue disorder and renal tubular structure damage，and the effect of high-dose group was more significant.Conclusion：Se enriched green tea can effectively alleviate the increase of blood pressure and improve the tissue structure damage of heart and kidney in rats fed with high salt diet.We can further to develop the corresponding functional food to play its health effect.

Key words： selenium enriched green tea; high-salt diet; hypertension prevention

心血管病是指包括冠心病、脑血管疾病、外周动脉疾病、先天性心脏病等在内的一组心脏和血管疾病.近年来，心血管病已超过癌症，成为导致死亡的主要病因^[1].高血压是与心血管病关联性最高的风险因素，据估计：在首次心脏病发作的人群中，患有高血压的占69%，在慢性心力衰竭的人群中占75%.临床资料显示：0.66 kPa降压可使卒中和缺血性心脏病的风险分别降低34%和21%^[2].茶在我国种植并饮用的历史已有近千年，被认为对人体健康有多种益处.越来越多的研究表明，茶对各种动物模型的血压都有有益的影响，比如研究发现：茶多酚、黄酮、儿茶素、表没食子儿茶素没食子酸酯均可以有效降低大鼠血压，其机制包括放松平滑肌、增强内皮一氧化氮合酶活性、减少血管炎症反应等^[3-4].本研究选用富硒绿茶水……