曾华

[摘要] 目的 對重组人粒细胞集落刺激因子（rhG-CSF）治疗化疗后白细胞减少的有效性进行分析。 方法 选取2017年1月至2019年10月我院经病理组织学检查确诊为恶性肿瘤化疗的86例患者，随机分分为两组，每组各43例。对照组给予鲨肝醇治疗，观察组给予rhG-CSF治疗。比较两组患者的抗生素使用率、不良反应发生率、治疗后WBC回升至正常时间以及治疗前后患者的生活质量变化差异。 结果 治疗后，观察组抗生素使用率为2.33%，对照组为18.60%，观察组低于对照组，差异有统计学意义（P<0.05）;观察组不良反应发生率为9.30%，对照组为27.91%，观察组低于对照组，差异有统计学意义（P<0.05）;观察组治疗后WBC回升至正常时间比较短于对照组，差异有统计学意义（P<0.05）。治疗后，两组在躯体功能、角色功能、认知功能、情绪功能和社会功能，观察组明显高于对照组，差异有统计学有意义（P<0.05）。 结论 在恶性肿瘤疾病化疗白细胞减少中rhG-CSF治疗方法所取得的临床治疗效果更为显著，减少抗生素使用率，降低不良反应发生率，应在疾病临床治疗中大力推广使用。

[关键词] 重组人粒细胞集落刺激因子;白细胞减少;rhG-CSF;不良反应

[中图分类号] R557.1          [文献标识码] B          [文章编号] 1673-9701（2021）13-0054-04

Analysis of the efficacy of recombinant human granulocyte colony-stimulating factor in the treatment of leukopenia after chemotherapy

ZENG Hua

Department of Medical Oncology， Ganzhou Municipal Hospital in Jiangxi Province， Ganzhou   341000， China

[Abstract] Objective To analyze the efficacy of recombinant human granulocyte colony-stimulating factor （rhG-CSF） in the treatment of leukopenia after chemotherapy. Methods A total of 86 patients who were diagnosed as malignant tumor chemotherapy by histopathological examination in our hospital from January 2017 to October 2019 were selected and randomly divided into the observation group（n=43） and the control group（n =43）.The control group was treated with batyl alcohol， while the observation group was treated with rhG-CSF. The differences in the antibiotic usage rate， the incidence of adverse reactions， the time needed for WBC to return to the normal condition after treatment and the change in the quality of life of the patients before and after treatment were observed between the two groups. Results After treatment， the antibiotic usage rate was 2.33% in the observation group， which lower than 18.60% in the control group， with statistically significant differences（P<0.05）; the incidence of adverse reactions was 9.30% in the observation group， which lower than 27.91% in the control group， with statistically significant differences（P<0.05）; the time needed for WBC to return to the normal condition in the observation group was lower than that in the control group， with statistically significant differences（P<0.05）; in terms of physical function， role function， cognitive function， emotional function and social function， the observation group was significantly higher than the control group， with statistically significant differences（P<0.05）. Conclusion rhG-CSF is more effective in the treatment of leukopenia caused by chemotherapy for malignant tumor. It can reduce the antibiotic usage rate and the incidence of adverse reactions， which should be widely promoted and used in clinical treatment of diseases.

[Key words] Recombinant human granulocyte colony-stimulating factor; Leukopenia; rhG-CSF; Adverse reactions

一般恶性肿瘤均需要进行化疗治疗，在化疗后患者会出现非髓源性中性粒细胞减少症等并发症，对化疗药物的使用造成较大的影响[1-2]，会对骨髓造成较大的抑制，进而导致白细胞（WBC）下降[3-4]，对化疗的使用剂量、进程及疗效均造成了较大的影响。为提升疾病临床治疗效果及质量，应对化疗药物对骨髓的抑制进行改善[5-6]。本研究将2017年1月至2019年10月经脱落细胞学及病理组织学检查被确诊为恶性肿瘤化疗的86例患者作为研究对象，对重组人粒细胞集落刺激因子（rhG-CSF）治疗化疗后白细胞减少的有效性进行分析，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年1月至2019年10月在我院经病理组织学检查确诊为恶性肿瘤化疗的86例患者，随机分为两组，每组各43例。对照组男21例，女22例，年龄43～72岁，平均（62.5±3.2）岁。疾病类型：乳腺癌16例，肺癌10例，结直肠癌7例，胃癌5例，其他恶性肿瘤5例。……