罗纯生　　展秀君　沈忠达　　沈萍　　吴媛媛

[摘要] 目的 探討机械性创伤患者血液检测指标变化与血栓形成的因素。 方法 选择2018年4月至2019年3月我院收治的50例机械性创伤伴血栓形成患者作为观察组，50例健康体检志愿者作为对照组，对两组对象的特异性生长因子、血小板、凝血、抗凝、纤溶系统进行检查。 结果 观察组特异性生长因子、血小板数量分别为（3.62±0.34）U/mL、（179.41±52.32）×109/mL，与对照组（3.54±0.25）U/mL、（166.18±46.38）×109/mL比较，差异无统计学意义（P>0.05）;观察组血小板聚集率为（67.58±21.33）%，高于对照组的（52.36±14.36）%，观察组血浆凝血酶原时间（9.24±1.23）s、凝血酶时间（21.89±1.26）s、抗凝血酶Ⅲ（68.93±15.66）%、纤溶酶原（74.68±16.33）%皆低于对照组血浆凝血酶原时间（11.65±1.22）s、凝血酶时间（25.68±1.54）s、抗凝血酶Ⅲ（96.42±11.54）%、纤溶酶原（89.47±15.64）%，观察组纤溶酶原激活物抑制物-1为（0.96±0.31）%，高于对照组的（0.63±0.19）%，差异有统计学意义（P<0.05）。 结论 机械性创伤患者的特异性生长因子和血小板数量基本不影响血栓的形成，但患者的血小板聚集率、血浆凝血酶原时间、凝血酶时间、特抗凝血酶Ⅲ、纤溶酶原、纤溶酶原激活物抑制物-1的含量变化都易影响血栓的形成。

[关键词] 机械性创伤;特异性生长因子;血小板;凝血;抗凝;纤溶系统;血栓

[中图分类号] R654.4          [文献标识码] A          [文章编号] 1673-9701（2021）13-0013-04

Correlation analysis of blood test index changes and thrombosis in patients with mechanical trauma

LUO Chunsheng1   ZHAN Xiujun2   SHEN Zhongda2   SHEN Ping2   WU Yuanyuan2

1.Jiamusi Center Blood Station in Heilongjiang Province， Jiamusi   154000， China; 2.Department of Clinical Laboratory，Jiamusi Hospital of Traditional Chinese Medicine in Heilongjiang Province， Jiamusi   154000， China

[Abstract] Objective To explore the correlation between the changes in blood test indexes and thrombosis in patients with mechanical trauma. Methods A total of 50 mechanical trauma patients with thrombosis from April 2018 to March 2019 were selected as the observation group，and 50 healthy physical examination volunteers who were admitted to our hospital as the control group at the same time. The specific growth factors， platelets， coagulation， anticoagulation， and fibrinolysis systems of the two groups were detected. Results There was no significant difference between the observation group and the control group in the specific growth factors[（3.62±0.34）U/mL vs. （3.54±0.25）U/mL] and the number of platelets [（179.41±52.32）×109/mL vs. （166.18±46.38）×109/mL]， The difference was not statistically significant（P>0.05）. The platelet aggregation rate of the observation group was （67.58±21.33）%， higher than （52.36±14.36）% of the control group.The plasma prothrombin time （9.24±1.23） s， thrombin time （21.89±1.26）s， antithrombin Ⅲ（68.93±15.66）%， plasminogen （74.68±16.33）% of the observation group were lower than those[（11.65±1.22）s， （5.68±1.54）s， （96.42±11.54）%，（89.47±15.64）%] of the control group. The plasminogen activator inhibitor-1（0.96±0.31）% was greater than（0.63±0.19）% in the control group. The two groups of subjects′ index results were significantly different（P<0.05）. Conclusion The specific growth factors and the number of platelets in patients with mechanical trauma does not affect the formation of thrombus. However， the patient′s platelet aggregation rate， plasma prothrombin time， thrombin time， antithrombin Ⅲ， plasminogen， and fibrinolysis， the changes in the content of zymogen activator inhibitor-1 easily affect the formation of thrombus.

[Key words] Mechanical trauma; Specific growth factors; Platelets; Coagulation; Anticoagulation; Fibrinolytic system; Thrombus

机械性损伤是指机体受到外界的机械性暴力作用后，相应的组织和器官出现了结构破坏或功能的损伤[1]。在人体上是指有各种致伤工具以机械性的方式对人体的组织进行破坏的，所造成的损伤，是在生活中较为常见的损伤方式。程度较轻的机械性损伤只要经过一定的处理就能够得到恢复，较为严重的机械性损伤患者将需要进行住院治疗[2]。一些损伤较为严重的患者可能会出现血栓，即血流在患者血管内面剥落处或修补处的表面形成小块，进而对患者身体的血液循环造成阻碍，这将会对患者的伤口的恢复和治疗造成巨大的麻烦[3]。本研……