王志强 曹秋平 岳瑞文 周克飞 何孟霞 王凯锋 刘静 卢昭

摘要：目的 观察五虫通络胶囊在消渴病痹證治疗中的临床疗效。方法 用随机平行对照方法，将120例消渴病痹证患者随机分为治疗组和对照组，每组各60例。在基础治疗上对照组加予甲钴胺治疗，治疗组加予五虫通络胶囊治疗。疗程12周。观察治疗前后2组患者中医证候总积分、肌电图神经传导速度测定的变化情况。结果 12周治疗后2组中医证候总积分均较前降低，正中神经和腓总神经的感觉神经、运动神经传导速度均较治疗前增加;组间相比，治疗组中医证候积分、神经传导速度增加较前改善均更明显（P<0.05）;治疗组疗效明显优于对照组（P<0.05）。结论 五虫通络胶囊可明显改善消渴病痹证患者凉、麻、痛、痿的临床症状，增加运动和感觉神经传导速度，疗效好，且无明显不良反应，值得推广。

关键词：五虫通络胶囊;消渴病痹证;疗效观察

中图分类号：R255.6 文献标志码：B 文章编号：1007-2349（2021）04-0022-04

Observation on Therapeutic Effect of Wuchongtongluo Capsule in the Treatmentof Diabetes Patients with Bi Syndrome

WANG Zhi-qiang， CAO Qiu-ping， YUE Rui-wen， ZHOU Ke-fei，HE Meng-xia， WANG Kai-feng， LIU Jing， LU Zhao

（Traditional Chinese Medicine Hospital of Kaifeng City， Kaifeng 475001， China）

【Abstract】Objective： To observe the clinical effect of Wuchongtongluo Capsule in the treatment of diabetes patients with bi syndrome. Methods： 120 diabetic patients with bi syndrome were randomly divided into treatment group and control group by a randomized parallel control method， 60 cases per group. In the basic treatment， the control group was treated with mecobalamin and the treatment group was treated with Wuchongtongluo Capsule. 12 weeks was a course of treatment. The changes in the total scores of TCM syndromes and the measurement of nerve conduction velocity in the electromyography of the two groups before and after treatment were observed. Results： After 12-week treatment， the total scores of TCM syndromes in the two groups were lower than those of the pre-treatment and the sensory and motor nerve conduction velocities of the median nerve and common peroneal nerve increased when compared with those of the pre-treatment. In comparison between the two groups， the TCM syndrome scores and nerves conduction velocity of the treatment group increased more significantly than before （P<0.05）. The curative effect of the treatment group was significantly better than that of the control group （P<0.05）. Conclusion： Wuchongtongluo Capsule can significantly improve the clinical symptoms of coldness， numbness， pain and flaccidity in diabetes patients with bi syndrome and increase the motor and sensory nerve conduction speed of the patients， with a good curative effect and no obvious adverse reactions， worthy of application.

【Key words】Wuchong Tongluo Capsule;Diabetes with bi syndrome;Curative effect

消渴病痹证，现代医学称为糖尿病性周围神经病变（diabetic peripheral neuropathy，DPN），是最常见的一种糖尿病慢性并发症，患病率高，致残率高，DPN发生后5～10年内病死率可达高达25%～50%[1-2]。临床危害性极大，迫切需要简便、有效且依从性、安全性高的综合治疗模式。目前常用药物有甲钴胺、硫辛酸、前列地尔等，对改善DPN症状有一定疗效[3]，但单用临床疗效均不理想[4-5]，性价比并不令人满意，能够逆转DPN进展的特效药物尚待进一步探索[6]。

近年来，中医药在糖尿病慢性并发症防治方面彰顯独有的优势。消渴病痹证病程长，以四肢麻木（麻）、发凉（凉）、疼痛（痛）、肌肉松弛无力（萎）为主要证候特点，属中医“痹证”范畴。久病入络，久病必瘀，本院根据“络病学说”理论，遴选出地龙、全蝎、蜈蚣、水蛭、僵蚕等配合芍药甘草汤组成五虫通络胶囊，应用于糖尿病周围神经病变治疗，临床观察取得较好疗效，且安全性良好，无明显不良反应，现报道如下。……