李进

[摘要] 目的 研究銀杏叶提取物注射液联合经颅磁刺激治疗阿尔茨海默病的临床疗效。 方法 收集2018年3—12月本院神经内科收治的阿尔茨海默病患者80例，将其随机分为观察组及对照组，每组各40例。两组均采用银杏叶提取物注射液静脉治疗，在此基础上，对照组采用假性刺激治疗，观察组采用经颅磁刺激治疗。评价两组患者治疗前后认知及行为能力，神经心理症状及疗效。 结果 治疗前，两组MMSE、ADAS-cog、ADL、NPI和BEHAVE-AD量表评分比较，差异无统计学意义（P>0.05），治疗后，观察组MMSE、ADAS-cog、ADL、NPI和BEHAVE-AD量表评分比较，差异有统计学意义（P<0.05）。观察组治疗总有效率为92.50%（37/40），明显高于对照组的67.50%（27/40），差异有统计学意义（P<0.05）。 结论 阿尔茨海默病采用银杏叶提取物注射液联合经颅磁刺激治疗，提高了患者认知及行为能力，改善了患者神经心理学状况，临床效果显著。

[关键词] 阿尔茨海默病;经颅磁刺激;银杏叶提取物注射液;认知及行为;神经心理学

[中图分类号] R597;R749.1+6          [文献标识码] B          [文章编号] 1673-9701（2021）12-0043-04

Clinical efficacy of extract injection of ginkgo leaf combined with transcranial magnetic stimulation on Alzheimer′s disease

LI Jin

Department Ⅰ of Neurology， the Third People′s Hospital of Liaoyang City in Liaoning Province， Liaoyang   111000， China

[Abstract] Objective To research the clinical efficacy of extract injection of ginkgo leaf combined with transcranial magnetic stimulation on Alzheimer′s disease. Methods A total of 80 patients with Alzheimer′s disease admitted to the department of neurology of our hospital from March to December 2018 were collected and randomly divided into the observation group（n=40） and the control group （n=40）. Both groups were treated with extract injection of ginkgo leaf intravenously. On this basis，the control group was treated with pseudo-stimulation， while the observation group was treated with transcranial magnetic stimulation. The cognitive and behavioral abilities， neuropsychological symptoms and therapeutic efficacies of the two groups of patients were evaluated before and after treatment. Results There was no significant difference in the scales of MMSE， ADAS-cog， ADL， NPI and BEHAVE-AD between the two groups before treatment（P>0.05）. After treatment， there was significant difference in the scale scores of MMSE， ADAS-cog， ADL， NPI and BEHAVE-AD between the observation group and the control group， with statistically significant differences（P<0.05）. The total efficacy rate of treatment was 92.50% （37/40） in the observation group ，which was higher than that of 67.50% （27/40） in the control group，with statistically significant difference（P<0.05）. Conclusion The treatment of Alzheimer′s disease with extract injection of ginkgo leaf combined with transcranial magnetic stimulation can increase the cognitive and behavioral ability of patients and improve the neuropsychological status of patients with significant clinical efficacies.

[Key words] Alzheimer′s disease; Transcranial magnetic stimulation; Extract injection of ginkgo leaf; Cognition and behavior; Neuropsychology

阿爾茨海默病（Alzheimer disease，AD）是一种退行性病变，疾病发展隐匿且不可逆，导致老年患者的认知及行为能力显著下降，严重影响患者的生活质量及生命安全[1-2]。疾病的发展近年来有递增的趋势，据统计[3]，中国人口中约有阿尔茨海默病患者800万，但仍还在以每年30万以上的新病例数不断递增，阿尔茨海默病不但对人类个体造成身心健康及生活质量的严重影响，同时，对患者的家庭会造成负担，也会对社会的和谐稳定造成影响。临床目前暂缺乏防治该疾病或使疾病延缓发展的有效治疗方式。临床治疗多以药物应用为主，但临床治疗阿尔茨海默病的药物有限，且药物的副作用也会对患者的药物依从性造成影响。因此，针对阿尔茨海默病患者选用安全且有效的系统综合治疗研究具有重要的临床意义。经颅……