曲丹丹 张雪

【摘要】 目的：探究血清及尿液抗炎因子及促炎因子在感染性腎结石患者中的检测价值。方法：选取2018年12月-2019年12月于本院就诊的86例感染性肾结石患者为观察组，同时期的86名体检健康者为对照组。检测与比较两组的血清及尿液抗炎因子（IL-2及IL-10）及促炎因子（IL-1β及IL-6），同时比较观察组中不同S.T.O.N.E评分及白细胞水平者的检测结果，分析各指标与S.T.O.N.E评分及白细胞水平的关系。结果：观察组的血清及尿液IL-2均显著低于对照组（P<0.05），血清及尿液IL-10、IL-1β及IL-6均显著高于对照组（P<0.05），观察组中不同S.T.O.N.E评分及白细胞水平者的检测结果比较，差异均有统计学意义（P<0.05）。Spearman秩相关分析显示，血清及尿液IL-2与S.T.O.N.E评分及白细胞水平呈负相关（P<0.05），血清及尿液IL-10、IL-1β及IL-6与S.T.O.N.E评分及白细胞水平呈正相关（P<0.05）。结论：血清及尿液抗炎因子及促炎因子在感染性肾结石患者中呈现异常表达的状况，对于结石情况及炎性反应程度有较高的检测价值。

【关键词】 血清 尿液 抗炎因子 促炎因子 感染性肾结石 检测价值

Investigation on the Detection Value of Serum and Urine Antiinflammatory Factors and Proinflammatory Factors of Patients with Infectious Nephrolithiasis/QU Dandan， ZHANG Xue. //Medical Innovation of China， 2021， 18（07）： -162

[Abstract] Objective： To investigate the detection value of serum and urine antiinflammatory and proinflammatory factors of patients with infectious nephrolithiasis. Method：A total of 86 patients with infectious nephrolithiasisadmitted to our hospital from December 2018 to December 2019 were selected as the observation group， 86 healthy subjects during the same period were selected as the control group. Then the serum and urine antiinflammatory factors （IL-2 and IL-10） and proinflammatory factors （IL-1β and IL-6） of two groups were detected and compared， then the detection results of observation group with different S.T.O.N.E scores and leukocyte levels were compared， the relationship between those indexes and S.T.O.N.E scores， leukocyte levels were analyzed. Result： The serum and urine IL-2 of observation group were significantly lower than those of control group （P<0.05）， the serum and urine IL-10， IL-1β and IL-6 were significantly higher than those of control group （P<0.05）， the detection results of observation group with different S.T.O.N.E scores and leukocyte levels were compared， there were statistically significant differences （P<0.05）. The Spearman rank correlation analysis showed the serum and urine IL-2 were negatively correlated with S.T.O.N.E scores and leukocyte levels （P<0.05）， the serum and urine IL-10， IL-1β and IL-6 were positively correlated with S.T.O.N.E scores and leukocyte levels （P<0.05）. Conclusion： The serum and urine antiinflammatory and proinflammatory factors of patients with infectious nephrolithiasis show abnormal expression state， the detection value for nephrolithiasis situation and inflammatory response degree are higher.

[Key words] Serum Urine Antiinflammatory factors Proinflammatory factors Infectious nephrolithiasis

Detection value

First-authors address： Jiamusi Central Hospital， Jiamusi 154002， China

doi：10.3969/j.issn.1674-4985.2021.07.038

肾结石是泌尿系常见病，且以青壮年多见，对患者造成较大不适感。另外，肾结石患者中部分为感染性肾结石，对患者的危害进一步加大，对于本类患者的研究占比也较高。本类患者因感染的存在，可导致炎性反应增强，相关的抗炎因子及促炎因子呈现一定的变化[1-2]，但是此类变化在感染性肾结石中的检测价值仍有待进一步深入探究，尤其是其对于结石情况及炎性反应程度的反应意义研究空间较大。本研究就血清及尿液抗炎因子及促炎因子在感染性肾结石患者中的检测价值进行探究，现报道如下。

1 资料与方法

1.1 一般资料 选取2018年12月-2019年12月于本院就诊的86例感染性肾结石患者为观察组，同时期的86名体检健康者为对照组。纳入标准：符合感染性肾结石诊断标准;20～65岁者;男女不限。排除标准：合并其他感染;合并慢性基础疾病;合并创伤;妊娠期及哺乳期;合并多系统器官功能不全;临床资料不完整。……