徐跃心 董慧静

[摘要] 目的 探讨血清抗苗勒管激素（AMH）结合性激素评估长期从事美业人员（美容、美发、美甲等）卵巢功能的效果。 方法 2019年3—10月招募从事美业行业志愿者100名作为实验组，同期选取来长治市人民医院体检的非美业人员60名作为对照组。时间分辨荧光免疫分析法测定抗苗勒管激素，化学发光法测定性激素，主要包括卵泡刺激素（FSH）、黄体生成素（LH）。根据职业不同分为实验组和对照组，后根据工作年限不同将实验组分为A组（≥5年且<10年）和B组（≥10年），比较各组AMH和性激素水平。并计算实验组和对照组AMH<1.1 ng/mL和FSH/LH≥2的发生率。 结果 实验组AMH值水平明显低于对照组，差异有统计学意义（P<0.05）;实验组LH、FSH水平明显高于对照组，差异有统计学意义（P<0.05）。实验组AMH<1.1 ng/mL患者的AMH平均水平明显低于对照组，差异有统计学意义（P<0.05）;实验组AMH<1.1 ng/mL及FSH/LH≥2发生率高于对照组，但差异无统计学意义（P>0.05）。随着工作年限的延长，B组AMH水平明显低于A组，FSH水平明显高于A组，差异有统计学意义（P<0.05），LH水平也有所升高，但差异无统计学意义（P>0.05）。 结论 暴露于化学制品的美业人员对其卵巢功能有一定影响，其影响力随工作年限逐渐增加。

[关键词] 抗苗勒管激素;卵泡刺激素;黃体生成素;卵巢功能

[中图分类号] R711.75          [文献标识码] B          [文章编号] 1673-9701（2021）08-0064-04

Evaluation of ovarian function of beauty professionals by anti-mullerian hormone combined with sex hormone

XU Yuexin1， 2   DONG Huijing3

1.Changzhi Medical College， Changzhi   046000， China; 2.Changzhi people′s Hospital in Shanxi Province， Changzhi  046000， China; 2.Juancheng County People′s Hospital in Shandong Province， Heze   274600， China

[Abstract] Objective To explore serum anti-mullerian hormone（AMH） and sex hormones in evaluating the ovarian function of people who have long been engaged in the beauty industry（beauty， hairdressing， nail art）. Methods From March to October in 2019， one hundred volunteers engaged in the beauty industry were recruited as the experimental group. Simultaneously， a total of 60 non-beauty industry personnel who came to Changzhi People′s Hospital for physical examination during this period were selected as the control group. The anti-mullerian hormone was measured by time-resolved fluorescence immunoassay. The main sex hormones measured by chemiluminescence were follicle stimulating hormone（FSH） and luteinizing hormone（LH）. According to different occupations， they were divided into experimental group and control group. Then according to different working years， the experimental group was divided into group A（≥5 years and <10 years） and group B（≥10 years）. The incidences of AMH<1.1 ng/mL and FSH/LH≥2 in  experimental group and control group were calculated. Results The level of AMH in the experimental group was significantly lower than that in the control group（P<0.05）; the level of LH and FSH in the experimental group was significantly higher than that in the control group（P<0.05）. The average level of AMH in the experimental group with AMH< 1.1 ng/mL was significantly lower than that in the control group（P<0.05）; the incidence of AMH<1.1 ng/mL and FSH/LH≥2 in the experimental group was higher than that in the control group， but the difference was not statistically significant（P>0.05）. With the extension of working years， the level of AMH in group B was significantly lower than that in group A， the level of FSH was significantly higher than that in group A， the difference was statistically significant（P<0.05）， and the level of LH was also increased， but the difference was not statistically significant（P>0.05）. Conclusion Exposure to chemicals has a certain effect on the ovarian function of beauty professionals， and their influence gradually increases with working years.

[Key words] Anti-mullerian hormone; Follicle stimulating hormone; Luteinizing hormone; Ovarian function

据有关部门统计[1]，职业女性约占妇女总人数的68%，在全部从业人员女性中约占45%。职业女性的健康意识与行为方式将直接影响一个家庭、一个群体的健康，乃至人口素质和社会的发展。女性有其自身的解剖生理特点，职业活动中的各种有害因素不仅使女性遭受职业病的潜在危险，还可能影响其生育能力。有研究表明[2]，各种各样的环境应激如生活和工作暴露均可干扰女性的生殖健康和月经功能;随着国内外一些新兴行业的兴起，从事美业行业的人员越来越多，其中大部分为女性，而从事此行业（本文主要探讨从事美容、美发、美甲等相关行业人员）过程中会长期暴露于各种化工原料中，目前国内对美业行业女性生殖健康影响的报道不多，机制研究更是处于滞后状态。……