曹玺 和丽生 刘因华 张娅 夏亮 李琴 陈茹

摘要：目的研究青刺果油皮炎凝胶抗炎止痒作用。方法60只雄性小鼠随机分为6组，包括模型对照组、凝胶基质对照组、复方醋酸地塞米松乳膏组和青刺果油皮炎凝胶低、中、高剂量组，采用二甲苯致小鼠耳廓肿胀实验观察其抗炎作用;60只豚鼠随机分为6组，包括模型对照组、凝胶基质对照组、糠酸莫米松凝胶组和青刺果油皮炎凝胶低、中、高剂量组，采用磷酸组织胺致豚鼠瘙痒观察其止痒作用。结果青刺果油皮炎凝胶中、高剂量组能极显著抑制小鼠耳廓肿胀（P<0.01），低剂量组能显著抑制小鼠耳廓肿胀（P<0.05）;青刺果油皮炎凝胶低、中、高剂量组肿胀抑制率分别为16.17%、32.30%、23.57%。青刺果油皮炎凝胶高剂量组有极显著增高豚鼠致痒阈作用（P<0.01）。结论青刺果油皮炎凝胶具有抗炎、止痒作用。

关键词：青刺果油皮炎凝胶;抗炎;止痒

中图分类号：R285.5文献标志码：A文章编号：1007-2349（2021）02-0064-03

Experimental Study on Anti-inflammatory and Antipruritic Effects

of Prinsepia Utilis Royle Extract Dermatitis Gel

CAO Xi， HE Li-sheng， LIU Yin-hua， ZHANG Ya， XIA Liang， LIi Qin， CHEN Ru

（Yunnan Institute of Traditional Chinese Medicine and Materia Medica， Kunming 65022， China）

【Abstract】Objective： To study the anti-inflammation and antipruritic effects of Prinsepia Utilis Royle Extract Dermatitis Gel. Methods： 60 male mice were randomly divided into 6 groups， including model control group， gel matrix control group， compound dexamethasone acetate cream group， and low， medium， and high-dose groups of Prinsepia Utilis Royle Extract Dermatitis Gel. Histamine phosphate was used to induce the ear swelling in mice to observe its anti-inflammatory effect. 60 guinea pigs were randomly divided into 6 groups， including model control group， gel matrix control group， mometasone furoate gel group and Prinsepia Utilis Royle Extract Dermatitis Gel groups of low， medium and high doses. The antipruritic effect of histamine phosphate in the guinea pigs was observed. Results： The medium and high-dose groups of Prinsepia Utilis Royle Extract Dermatitis Gel could very significantly inhibit the ear swelling of the mice （P<0.01）， and the low-dose group could significantly inhibit the ear swelling of the mice （P<0.05）. The swelling inhibition rates of Prinsepia Utilis Royle Extract Dermatitis Gel of low， medium and high dose groups were 16.17%， 32.30% and 23.57% respectively. The high-dose group of Prinsepia Utilis Royle Extract Dermatitis Gel had a very significant effect on increasing the itching threshold of guinea pigs （P<0.01）. Conclusion： Prinsepia Utilis Royle Extract Dermatitis Gel has anti-inflammatory and antipruritic effects.

【Key words】Prinsepia Utilis Royle Extract Dermatitis Gel;Anti-inflammatory;Antipruritic

青刺果為蔷薇科植物总花扁核木（Prinsepia utilis Royle）的果实，别名青刺尖、打油果、青那果、狗奶子、炮筒果、梅花刺、打枪果、枪子果、阿那斯（纳西族），出裸（彝族），生长于海拔1800～3000m的山坡、荒地、地边、路边和背阴灌丛中，在寒冷的冬季仍具极强生命力，在我国云南、四川和贵州等省均有分布，云南以丽江及其周边地区为主要产地。青刺果在云南民间具有悠久的药用历史，根、叶、果均可入药或食用，具有清热、解毒、健胃等作用[1-2]。

在东巴文记载的历史中，青刺果被视为“吉祥树”和“百花之王”。青刺果油对多种细菌、酵母菌和霉菌都有很好的抑菌效果[3-5]。皮肤涂抹青刺果油用于清热消炎、排毒解毒;冬季手足干燥、开裂，用青刺果油涂抹能使皮肤润泽嫩滑，并能治疗冻疮;外用青刺果油，对缓解脚气（香港脚）有明显疗效等。……