齐霁 孙明谨

【摘要】 目的：探討2型糖尿病（T2DM）患者肾功能指标与认知功能的关系。方法：选择2019年3月-2020年10月就诊于湖北医药学院附属随州医院内分泌科的T2DM患者作为研究对象，对其进行简易智力状态检查量表（MMSE）检测，对于排除痴呆的患者进行蒙特利尔认知评估量表（MoCA）检测，共收集数据185例，根据MoCA得分分为认知功能障碍组98例和认知功能正常组87例。分析两组患者MoCA各项得分情况，收集两组患者的年龄、性别、病程、受教育年限、体重指数、糖化血红蛋白、肌酐、血清尿酸、尿微量白蛋白，尿β2-微球蛋白等信息，并根据简化MDRD公式计算肾小球滤过率。结果：认知功能障碍组患者的视空间与执行能力、抽象思维能力、命名能力、定向能力、延迟记忆能力、注意力、语言能力得分均低于认知功能正常组，差异均有统计学意义（P<0.05）。认知功能障碍组患者血清尿酸水平、肾小球滤过率、受教育年限均低于认知功能正常组（P<0.05），年龄、女性占比均高于认知功能正常组（P<0.05）。二元logistic回归分析结果显示，年龄、受教育年限、血清尿酸水平、eGFR与T2DM患者发生认知功能障碍有关（P<0.05）。结论：T2DM患者发生认知功能障碍时，表现为视空间与执行能力、抽象思维能力、命名能力、定向能力、延迟记忆能力、注意力、语言能力均降低;年龄、受教育年限、血清尿酸水平、eGFR与T2DM患者发生认知功能障碍有关。

【关键词】 2型糖尿病 认知功能 肾功能 血清尿酸 肾小球滤过率

Correlation Analysis of Renal Function Indexes and Cognitive Function in Patients with T2DM/QI Ji， SUN Mingjin. //Medical Innovation of China， 2021， 18（33）： 0-049

[Abstract] Objective： To explore the relationship between renal function indexes and cognitive function in patients with type 2 diabetes mellitus （T2DM）. Method： T2DM patients in the Department of endocrinology of Suizhou Hospital Affiliated to Hubei Medical College from March 2019 to October 2020 were selected as the research objects， they were tested with the simple mental state examination scale （MMSE）， and the patients excluding dementia were tested with the Montreal cognitive assessment scale （MoCA）， a total of 185 cases of data were collected， according to MOCA score， 98 cases were divided into the cognitive dysfunction group and 87 cases were divided into the normal cognitive function group. The scores of MoCA in two groups were analyzed， and the information of age， sex， course of disease， years of education， body mass index， glycosylated hemoglobin， creatinine， serum uric acid， urinary microalbumin， urinary β2-microglobulin and other information of patients in two groups were collected， the glomerular filtration rate was calculated according to the simplified MDRD formula. Result： The scores of visual space and executive ability， abstract thinking ability， naming ability， orientation ability， delayed memory ability， attention and language ability of patients in the cognitive dysfunction group were lower than those in the normal cognitive function group， the differences were statistically significant （P<0.05）. The levels of serum uric acid， glomerular filtration rate， and years of education of patients in the cognitive dysfunction group were lower than those in the normal cognitive function group （P<0.05）， and the proportions of age and women were higher than those in the normal cognitive function group （P<0.05）. The results of binary logistic regression analysis showed that age， years of education， serum uric acid level， and eGFR were related to cognitive dysfunction in T2DM patients （P<0.05）. Conclusion： When cognitive dysfunction occurs in patients with T2DM， it is manifested as decreased visual space and executive ability， abstract thinking ability， naming ability， orientation ability， delayed memory ability， attention and language ability; age， years of education， serum uric acid level and eGFR are related to cognitive dysfunction in T2DM patients.

[Key words] Type 2 diabetes mellitus Cognitive function Renal function Serum uric acid Glomerular filtration rate

First-author’s address： Jinzhou Medical University， Jinzhou 121001， China

doi：10.3969/j.issn.1674-4985.2021.33.012

2型糖尿病（type 2 diabetes mellitus，T2DM）近年来患病率急剧上升，其特征表现为持续的高血糖状态以及不断加重的胰岛素抵抗，常合并各种慢性并发症。……