张晨光 付信 万玲君 韩子华

[摘要] 目的 探討营养支持联合抗阻运动改善晚期前列腺癌患者营养状况和癌因性疲乏的效果。 方法 选取2015年1月至2019年12月我院泌尿科门诊就诊的晚期前列腺癌患者68例，采用随机数字法将患者分为干预组和对照组，每组各34例。对照组患者予营养支持方案，干预组患者在对照组基础上予抗阻运动锻炼，两组患者均干预8周。评估并比较两组患者干预前后营养状况[血清血红蛋白（Hb）、白蛋白（ALB）和肱三头肌皮褶厚度（TSF）、多维疲乏症状简表（MFSI-SF）及体力状况（KPS评分）]的变化。 结果 干预8周后，两组患者血清Hb和ALB水平、TSF显著上升（P<0.05或P<0.01），且干预组患者上升幅度较对照组更显著（P<0.05）;同时两组患者MFSI-SF评分显著下降，KPS评分显著上升（P<0.05或P<0.01），且干预组患者变化幅度较对照组更显著（P<0.05）。 结论 营养支持联合抗阻运动用于晚期前列腺癌患者不仅可提高营养状况，减少营养不良发生，而且可缓解癌因性疲乏症状，增强体力状况。

[关键词] 晚期前列腺癌;营养支持;抗阻运动;营养状况;癌因性疲乏

[中图分类号] R737.25          [文献标识码] B          [文章编号] 1673-9701（2021）36-0080-04

Effects of nutritional support combined with resistance exercise on the improvement of the nutritional status and cancer-related fatigue in the patients with advanced prostate cancer

ZHANG Chenguang1   FU Xin2   WAN Lingjun1   HAN Zihua1， 3

1.Department of Urology， Taizhou Hospital of Zhejiang Province， Linhai   317000， China; 2.Department of Radiotherapy， Taizhou Hospital of Zhejiang Province， Linhai   317000， China; 3.Department of Urology， Taizhou Enze Medical Center （Group） Enze Hospital， Taizhou   318050， China

[Abstract] Objective To explore the effect of nutritional support combined with resistance exercise on the improvement of the nutritional status and cancer-related fatigue in the patients with advanced prostate cancer. Methods A total of 68 patients with advanced prostate cancer who were admitted to the clinic of urology in our hospital from January 2015 to December 2019 were selected. The patients were divided into intervention group and control group by random number method， with 34 cases in each group. Patients in the control group were given nutritional support， and patients in the intervention group were given resistance exercises on the basis of the control group. Patients in both groups were intervened for 8 weeks. The nutritional status （serum hemoglobin [Hb]， albumin [ALB] and triceps skinfold thickness [TSF]， changes in Multidimensional Fatigue Symptom Summary [MFSI-SF] and physical status [KPS score]） were assessed and compared between the two groups before and after intervention. Results After 8 weeks of intervention， the serum Hb and ALB levels and TSF in both groups were increased significantly （P<0.05 or P<0.01）， and the increase in the patients in the intervention group was more significant than that in the control group（P<0.05）; at the same time， the MFSI-SF score in both groups was decreased significantly， and the KPS score was increased significantly （P<0.05 or P<0.01）. The range of changes in the intervention group was more significant than that in the control group（P<0.05）. Conclusion Nutritional support combined with resistance exercise for patients with advanced prostate cancer can not only improve the nutritional status and reduce the occurrence of malnutrition， but also alleviate the symptoms of cancer-related fatigue and enhance the physical status.

[Key words] Advanced prostate cancer; Nutritional support; Resistance exercise; Nutritional status; Cancer-related fatigue

前列腺癌是一种泌尿系统较常见的恶性肿瘤，其临床症状与良性前列腺增生相类似，易发生误诊误治，近年来其发病率及死亡率较高[1-2]。营养不良及癌因性疲乏是晚期肿瘤最常见的伴随症状之一，对患者心理和生理影响较大，从而加重患者的病情，使得患者的生活质量下降，给患者家庭及社会造成巨大负担，是直接致使患者死亡的重要因素[3-4]。……