王顺平

【摘要】 目的：分析糠酸莫米松联合氯雷他定对过敏性鼻炎患者的临床效果。方法：选择2018年7月-2019年7月笔者所在医院收治的过敏性鼻炎患者77例，按随机数字表分为两组，对照组38例使用氯雷他定治疗，研究组39例在对照组基础上使用糠酸莫米松治疗，对两组临床效果进行比较。结果：研究组治疗后临床症状评分明显低于对照组，生活质量评分高于对照组（P<0.05）;研究组治疗后IL-10水平高于对照组，TNF-α水平低于对照组（P<0.05）;研究组头痛、口干、嗜睡等不良反应发生率为2.56%，低于对照组的21.05%（P<0.05）。结论：采用糠酸莫米松联合氯雷他定治疗过敏性鼻炎，可改善患者临床症状，有效提高生活质量及免疫力，且不良反应少，安全性高，值得在临床中推广使用。

【关键词】 糠酸莫米松 氯雷他定 过敏性鼻炎 临床效果

doi：10.14033/j.cnki.cfmr.2020.15.019 文献标识码 B 文章编号 1674-6805（2020）15-00-02

Clinical Effect of Mometasone Furoate Combined with Loratadine in Patients with Allergic Rhinitis/WANG Shunping. //Chinese and Foreign Medical Research， 2020， 18（15）： -46

[Abstract] Objective： To analyze the clinical effect of Mometasone Furoate combined with Loratadine in patients with allergic rhinitis. Method： A total of 77 patients with allergic rhinitis treated in our hospital from July 2018 to July 2019 were selected and divided into two groups according to the random number table. And 38 patients in the control group were treated with Loratadine， and 39 patients in the study group were treated with Mometasone Furfurate on the basis of the control group. The clinical effects of the two groups were compared. Result： After treatment， the clinical symptom score of the study group was significantly lower than that of the control group， and the quality of life score was higher than that of the control group （P<0.05）. The level of IL-10 in the study group was higher than that of the control group， and the level of TNF-α was lower than that of the control group （P<0.05）. The incidence of adverse reactions such as headache， dry mouth and drowsiness was 2.56% in the study group， which was lower than 21.05% of the control group （P<0.05）. Conclusion： The Mometasone Furoate combined with Loratadine in the treatment of allergic rhinitis can improve the clinical symptoms of patients， effectively improve their quality of life and immunity， and has fewer adverse reactions and high safety， and is worth promoting in clinical practice.

[Key words] Mometasone Furoate Loratadine Allergic rhinitis Clinical effect

First-authors address： Foshan Stomatological Hospital Affiliated to Foshan University of Science and Technology， Foshan 528000， China

過敏性鼻炎在耳鼻喉科中是一种常见疾病，以打喷嚏、鼻痒、鼻塞、流涕等为临床症状，若不及时接受有效治疗，可诱发多种并发症，如哮喘、分泌性中耳炎、鼻窦炎等，严重影响患者身心健康[1]。据有关调查显示，随着环境污染日益加重，我国过敏性鼻炎发病率呈逐年上升趋势[2]。本研究对笔者所在医院于2018年7月-2019年7月收治的过敏性鼻炎患者77例采取不同治疗方案并进行分析，报道如下。

1 资料与方法

1.1 一般资料

选择2018年7月-2019年7月笔者所在医院收治的过敏性鼻炎患者77例。纳入标准：符合过敏性鼻炎诊断标准;临床依从性高。排除标准：近期有抗过敏性药物史;存在心、肝、肾等重要脏器严重疾病;伴有系统性疾病;伴有精神障碍疾病;中途退出本次研究。按随机数字表分为两组，对照组38例，男18例，女20例;年龄21～49岁，平均（32.17±6.08）岁;病程5个月～5年，平均（2.89±0.74）年。研究组39例，男19例，女20例;年龄22～48岁，平均（31.45±5.83）岁;病程5个月～4年，平均（2.97±0.82）年。两组一般资料比较，差异无统计学意义（P>0.05）。本研究获伦理委员会同意，所有患者均签订同意书。