苏亚娇　秦真威　范红敏

摘要 目的 探讨高温作业对男性钢铁工人尿酸的影响。方法 采用随机整群抽样方法选取某钢铁集团2018年3—5月期间进行职业健康体检的657名男性钢铁工人作为研究对象，通过问卷调查、体格检查以及实验室检查获得工人的基本信息，运用单因素和多因素Logistic回归分析高温作业对高尿酸血症（HUA）的影响。结果 男性钢铁工人HUA的检出率为33.2%。单因素分析显示，高温暴露者HUA检出率高于非高温暴露者，差异有统计学意义（P<0.001）。多因素Logistic回归分析结果显示，高温暴露对HUA的影响差异无统计学意义（P>0.05），年龄、体质量指数（BMI）对HUA的影响差异有统计学意义（P<0.05）。结论 男性钢铁工人高温暴露对HUA无影响，年龄和BMI是主要影响因素。

关键词 高温作业;男性钢铁工人;高尿酸血症

中图分类号  R131    文献标识码  A    文章编号  1671-0223（2020）10-081-04

EFFECT OF HIGH-TEMPERATURE OPERATION ON THE HYPERURICEMIA IN MALE STEEL WORKERS Su Yajiao，Qin Zhenwei，Fan Hongmin. School of Public Health， North China University of Science and Technology， Tangshan 063210， China

Abstract  Objective To explore the effect of high temperature on uric acid in male steelworkers.Methods Using random cluster sampling method to select a certain iron and steel group during March to May 2018  in occupational health examination of 657 male workers as the research object through questionnaire investigation，physical examination and laboratory examination to obtain the basic information of the workers， using the single factor and multiple factors Logistic regression analysis of the influence of hot work for uric acid.Results The detection rate of hyperuricemia in male steel workers was 33.2%，Univariate analysis showed that the detection rate of hyperuricemia in high temperature exposed subjects was higher than that in non-high temperature exposed subjects，the difference was statistically significant（P<0.001）.After adjusting for multiple factors，the results showed no statistical significance between high temperature exposure and hyperuricemia （P>0.05），the effects of age and BMI on hyperuricemia were statistically significant （P<0.05）.Conclusion High temperature exposure is not associated with hyperuricemia in male steel workers，with age and BMI being the main influencing factors.

Key words  High temperature operation;Male steelworkers;Hyperuricemia

高尿酸血症（hyperuricemia，HUA）是嘌呤代谢紊乱的结果，其不仅与痛风有关，最直接的结果就是导致痛风的发作，随访研究发现18.8%的HUA患者在5年内会发展为痛风[1]，还与心血管疾病、慢性肾病、代谢综合征的发生发展有着密切的联系[2-3]。国内外流行病学资料均显示，随着经济水平的发展，HUA的患病率呈逐年升高趋势。据报道我国约有HUA患者1.2亿人[4]，一般人群中男性HUA的患病率为21.6%[5]，由于某些特殊职业因素（倒班、高温、噪声等）的存在导致部分职业人群（如钢铁工人）HUA的患病率明显高于该水平。

高温是一种职业性有害因素，国内外相关研究发现高温对钢铁作业工人的影响是多方面的，可造成機体一系列的生理功能改变[6]，引起体温、代谢、消化系统、循环系统等发生异常，长期暴露于高温的环境中会对职业人群的健康造成……