刘卓超 黄小靖 刘翠玲 尹建平 陈柏书

摘要 目的：探讨万全《万氏妇人科》治疗产后病的处方用药规律。方法：运用中医传承辅助平台（V2.5），将《万氏妇人科》中治疗产后病的55首方剂录入，利用该软件的集成规则分析、改进的互信息法、复杂系统熵聚类、无监督的熵层次聚类数据分析等方法分析挖掘明代万全治疗妇人产后病的用药经验。结果：对55首方剂进行数据分析，药物甘草、当归、人参分别是单味药物使用频次的前3位。药物组合排列前3的分别为人参、甘草;生姜、甘草;甘草、当归。提取到3个治疗产后病的新处方：蒲黄、红花、人参、牡丹皮、补骨脂;川芎、香附、延胡索、牡丹皮、补骨脂;甘草、陈皮、干姜、牡丹皮、补骨脂。结论：万全以益气养血为治疗产后病的主要治法，根据不同兼证加减治疗，同时药物配伍甘平缓和。

关键词 产后病;中医传承辅助平台;用药规律

Study on Medication Rule of WanShi FuRenKe in the Treatment of Postpartum Disease Based on Analysis of Data Mining

LIU Zhuochao，HUANG Xiaojing，LIU Cuiling，YIN Jianping，CHEN Boshu

（Shenzhen Baoan Hospital of Traditional Chinese Medicine （Group），Affiliated to Guangzhou University of Chinese Medicine，Shenzhen 518000，China）

Abstract Objective：To analyze and excavate the prescription law of WanShi FuRenKe in the treatment of postpartum disease by using TCM inheritance assistant platform.Methods：By collecting prescriptions of WanShi FuRenKe to treat postpartum，55 prescriptions were input into TCM inheritance auxiliary platform （V2.5）.The data of medication rule was mined by his integrated rule analysis，improved mutual information method，complex system entropy clustering，unsupervised entropy hierarchical clustering data analysis and other methods to analyze and mine the drug use experience of WanQuan in the treatment postpartum diseases in the Ming Dynasty.Results：According to the data analysis of 55 prescriptions，Radix Glycyrrhizae，Radix Angelicae and Radix Ginseng were the most frequently used herbs.The top 3 herbs combinations were Radix Ginseng and Radix Glycyrrhizae; Rhizoma Zingiberis Recens and Radix Glycyrrhizae，Radix Glycyrrhizae and Radix Angelicae.A total of 3 new prescriptions for postpartum disease were extracted：Polen Typhae，Flos Carthami，Radix Ginseng，Cortex Moutan Radicis and Fructus Psoraleae; Rhizoma Ligustici Chuanxiong，Rhizoma Cyperi，Rhizoma Corydalis，Cortex Moutan Radicis，Fructus Psoraleae; Radix Glycyrrhizae，Pericarpium Citri Reticulatae，Rhizoma Zingiberis，Cortex Moutan Radicis，Fructus Psoraleae.Conclusion：WanQuan takes nourishing qi and blood as the main treatment method for postpartum diseases，adding and subtracting treatment according to different syndromes.Meanwhile，the compatibility of drugs is smooth and mild.

Keywords Postpartum disease; Traditional Chinese medicine inheritance auxiliary platform; Medication rule

中图分类号：R271.43文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.24.028

妇人在新产后及产褥期内因气血大亏、脉络空虚所致诸疾均统称为“产后病”[1]。中医文献对产后病早有记载，《五十二病方》已有记载产妇子痫类似之症。明代万全所撰的《万氏妇人科》共分四卷，对中医治疗妇人病有重要影响，分别为：妇科杂病篇（卷一）、妊娠病篇（卷二）、产后病篇（卷三）及对前三卷的补充（卷四）[2]。本研究运用中医传承辅助平台（V2.5）挖掘分析《萬氏妇人科》卷三及卷四中治疗产后病方剂的药物使用频次、药物组合及关联规则等规律，探讨《万氏妇人科》治疗产后病的用药经验，以望为临床用药提供参考。……