陈培忠

[摘要] 目的 探讨泮托拉唑四联法不同疗程对胃溃疡合并糖尿病患者的疗效及复发率的影响。方法 纳入50例2017年5月—2018年5月该院胃溃疡合并糖尿病患者开展研究，所有患者均采用泮托拉唑、克拉霉素、阿莫西林、果胶铋四联法治疗，按随机排列法选出25例列为对照组：1个疗程;剩余25例列为研究组：3个疗程;比较两组对临床疗效及复发率的影响。结果 研究组总有效率为92.00%，高于对照组的76.00%，差异有统计学意义（P<0.05）;两组治疗结束1个月后Hp阳性率差异无统计学意义（P>0.05），治疗结束1年后研究组Hp阳性率及复发率均低于对照组，差异有统计学意义（P<0.05）;两组血糖水平对比，治疗前差异无统计学意义（P>0.05），治疗后，研究组空腹及餐后2 h血糖均低于对照组，差异有统计学意义（P<0.05）。结论 在胃溃疡合并糖尿病患者的治疗中，泮托拉唑四联法3个疗程疗效优于1个疗程，可提高临床有效率，降低Hp阳性率及复发率，有效控制患者血糖水平，值得推广。

[关键词] 泮托拉唑;四联法;不同疗程;胃溃疡;糖尿病

[中图分类号] R4          [文献标识码] A          [文章编号] 1672-4062（2020）01（b）-0092-03

[Abstract] Objective To investigate the effect of pantoprazole quadruple therapy on the efficacy and recurrence rate of patients with gastric ulcer and diabetes mellitus. Methods A total of 50 patients with gastric ulcer and diabetes mellitus were enrolled in the hospital from May 2017 to May 2018. All patients were treated with pantoprazole， clarithromycin， amoxicillin and pectin were randomly selected. Listed as the control group： 1 course of treatment; the remaining 25 cases were included in the study group： 3 courses; the effects of the two groups on clinical efficacy and recurrence rate were compared. Results The total effective rate of the study group was 92.00%， which was higher than 76.00% of the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference in Hp positive rate after 1 month of treatment（P<0.05）. The Hp positive rate and recurrence rate of the study group 1 year after the end of treatment. The blood glucose levels were lower than those in the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference between the two groups （P>0.05）. After treatment， the blood glucose of the study group was lower than that of the control group，and the difference was statistically significant（P<0.05）. Conclusion In the treatment of patients with gastric ulcer and diabetes， the pantoprazole quadruple method is better than one course of treatment， which can improve clinical efficiency， reduce Hp positive rate and recurrence rate， and effectively control blood glucose level of patients. It is worthy of promotion.

[Key words] Pantoprazole; Quadruple method; Different courses of treatment; Gastric ulcer; Diabetes]

糖尿病是一種代谢性疾病，属慢性病范畴，由于内分泌紊乱引起，胰岛素分泌过少或作用障碍造成高血糖。糖尿病患者因其血糖长期处于高值，伴有血液黏度的升高，造成胃、十二指肠发生循环障碍，进而黏膜发生坏死，降低细胞再生性功能，从而引起胃溃疡等胃肠道疾病。糖尿病合并胃溃疡的发生会加重病情的发展，不利于原发病的预后，故应采取有效的治疗方式提高临床疗效，从而提高患者的生活质量[1]。泮托拉唑是临床上常用的质子泵抑制剂，该次以该院于2017年5月—2018年5月收治的50例胃溃疡合并糖尿病患者为对象，就克拉霉素、阿莫西林、果胶铋四联法的不同疗程对临床疗效及复发率的影响展开讨论，现报道如下。