薛立江

[摘要] 目的 分析二甲双胍联合瑞格列奈治疗社区2型糖尿病患者的效果。方法 按照该院收治的100例患者先后顺序，将其划分为两组。2018年1—6月收治的50例纳入对照组，采取常规护理+二甲双胍干预;2018年7月—2019年1月收治的50例纳入观察组，在对照组的基础上，加入瑞格列奈治疗。对两组患者的血糖控制状况与不良反应发生状况进行统计与比较。结果 两组患者干预前的血糖指标比较，差异无统计学意义（P>0.05）;在干预后，观察组患者的血糖指标改善状况明显优于对照组，差异有统计学意义（P<0.05）。两组患者的不良反应发生状况比较，差异无统计学意义（P>0.05）。结论 二甲双胍联合瑞格列奈治疗社区2型糖尿病患者的临床效果较好，能够对其血糖进行有效控制，降低并发症的发生，且不良反应发生率较低，值得临床推广。

[关键词] 二甲双胍;瑞格列奈;社区2型糖尿病;效果

[中图分类号] R781          [文献标识码] A          [文章编号] 1672-4062（2020）01（b）-0088-02

[Abstract] Objective To analyze the effect of metformin combined with repaglinide in the treatment of type 2 diabetes in the community. Methods According to the order of 100 patients admitted to the hospital， they were divided into 2 groups. 50 patients admitted to the control group from January to June 2018 were enrolled in the control group with routine nursing + metformin intervention; 50 patients admitted from July 2018 to January 2019 were included in the observation group， and on the basis of the control group， added repaglinide treatment. The blood glucose control status and adverse reaction occurrence status of the two groups of patients were counted and compared. Results There was no statistically significant difference in the blood glucose index between the two groups before intervention （P>0.05）. After the intervention， the improvement of blood glucose index in the observation group was significantly better than that in the control group， the difference was statistically significant （P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P>0.05）. Conclusion Metformin combined with repaglinide has a good clinical effect in the treatment of type 2 diabetes in the community. It can effectively control its blood glucose， reduce the incidence of complications， and the incidence of adverse reactions is low， which is worthy of clinical promotion.

[Key words] Metformin; Repaglinide; Community type 2 diabetes; Effect

隨着当前人们生活水平的不断提高，各种内分泌代谢性疾病的发生率相对增加。糖尿病作为临床相对典型的一种内分泌代谢类疾病，目前已经成为我国的基础性疾病之一，其具有覆盖面广，并发症发生率高，病程较长等诸多特点[1]。2型糖尿病作为常见的一类糖尿病，其以不可逆的胰岛素分泌障碍以及胰岛素抵抗为主要特点。在患病后，患者会存在明显的血糖偏高现象，如果不能及时对其血糖进行控制，随着病程的延长，个体诱发其他疾病的可能性增加，如心脑血管疾病、糖尿病足病、糖尿病视网膜病变等，这些将会对患者的生活质量造成极大的影响[2]。而在……