杨玉勤

[摘要] 目的 探究血清C肽、糖化血红蛋白二者联合检测在糖尿病临床诊断中的临床价值。方法 整理2018年1月—2019年2月期间该院内二科收治的56例糖尿病患者设为观察组，同期选择56名身体健康的老年人设为对照组。对两组进行血清C肽检测与糖化血红蛋白检测，分析两种检测方法的检测结果及临床检测价值。 结果 观察组的糖化血红蛋白、空腹血糖水高于对照组，观察组的血清C肽水平低于对照组。合并并发症患者的糖化血红蛋白、空腹血糖水高于无并发症患者，而合并并发症患者的血清C肽低于无并发症的患者。以上差异有统计学意义（P<0.05）。 结论 在糖尿病临床诊断中进行血清C肽、糖化血红蛋白检测，可显著提高诊断效果，有利于临床医师有效判断患者的病情严重程度，了解其血糖水平变化，为临床诊治提供有价值的依据。

[关键词] 血清C肽;糖化血红蛋白;糖尿病;临床价值

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1672-4062（2020）01（b）-0057-02

[Abstract] Objective To investigate the clinical value of combined detection of serum C-peptide and glycated hemoglobin in the clinical diagnosis of diabetes. Methods A total of 56 patients with diabetes mellitus admitted to the hospital from January 2018 to February 2019 were enrolled in the observation group. 56 healthy individuals were selected as the control group. Serum C-peptide detection and glycosylated hemoglobin were detected in both groups， and the detection results and clinical detection value of the two detection methods were analyzed. Results The glycated hemoglobin and fasting blood glucose in the observation group were higher than those in the control group. The serum C-peptide level of the observation group was lower than that of the control group. Glycated hemoglobin and fasting blood glucose were higher in patients with complications than in uncomplicated patients， and patients with complications had lower serum C-peptide than patients without complications. The above differences were statistically significant （P<0.05）. Conclusion The detection of serum C-peptide and glycosylated hemoglobin in the clinical diagnosis of diabetes can significantly improve the diagnostic effect， which is helpful for clinicians to effectively judge the severity of the patient's condition and understand the changes of blood glucose level， which provides a valuable basis for clinical diagnosis and treatment.

[Key words] Serum C-peptide; Glycated hemoglobin; Diabetes; Clinical value

糖尿病是常見的基础疾病之一，也是最为常见的一种代谢系统疾病，临床表现以血糖水平升高为主。于糖尿病患者而言，控制血糖是治疗该病症的治疗原则[1]。临床上常以胰岛素药物控制治疗为主要治疗方式控制病情。近年来，医学领域对糖尿病临床诊治效果的关注度较高，并做了许多创新与努力[2]。该研究对糖尿病患者进行血清C肽检测与糖化血红蛋白检测，旨在探究两种检测方法联合检测的效果。现分析2018年1月—2019年2月间该院内二科收治的56例糖尿病患者为临床资料，报道如下。

1  资料与方法

1.1  一般资料

整理在该院内二科住院期间的56例糖尿病患者的临床资料，包括30例男性、26例女性;年龄最大88岁，最小38岁，平均（58.63±2.15）岁;病程最长26年，最短7个月，平均（13.74±1.03）年;平均空腹血糖值>7.0 mmol/L，餐后2 h血糖值>12.0 mmol/L。对照……