李雁　吴海燕　王玉娥　李惠山

[摘要]目的 探討益生菌含片联合基础牙周治疗对慢性牙周炎伴口臭患者口腔微生态的影响。方法 选取我院2016年2月～2019年2月收治的74例慢性牙周炎伴口臭患者作为研究对象，按照随机数字表法分为观察组（37例）和对照组（37例），对照组采用基础牙周治疗，观察组采用益生菌含片联合牙周基础治疗，比较两组的唾液白介素-6、白介素-10、口腔致病菌群、基质金属蛋白酶-9的水平以及治疗效果。结果 观察组的唾液白介素-6和基质金属蛋白酶-9低于对照组，差异有统计学意义（P<0.05）。观察组白介素-10水平高于对照组，差异有统计学意义（P<0.05）。观察组口腔致病菌群各项均低于对照组，差异有统计学意义（P<0.05）。观察组临床治疗总有效率高于对照组，差异有统计学意义（P<0.05）。结论 在慢性牙周炎伴口臭患者中采用益生菌含片联合牙周基础治疗，可以有效降低白介素-6和基质金属蛋白质酶-9，提升白介素-10，改善口腔致病菌群，有较好的临床治疗效果，临床具有一定的运用价值，应该广泛运用于临床。

[关键词]益生菌含片;基础牙周治疗;慢性牙周炎;口臭;口腔微生态

[中图分类号] R781.3     [文献标识码] A     [文章编号] 1674-4721（2020）3（b）-0121-03

Effect of Probiotics Buccal Tablets combined with basic periodontal treatment on oral microecology of patients with chronic periodontitis accompanied by bad breath

LI Yan   WU Hai-yan   WANG Yu-e   LI Hui-shan

Department of Stomatology， Dalian Friendship Hospital， Liaoning Province， Dalian   116001， China

[Abstract] Objective To explore the effect of Probiotics Buccal Tablets combined with basic periodontal treatment on oral microecology of patients with chronic periodontitis accompanied by bad breath. Methods A total of 74 patients with chronic periodontitis accompanied by bad breath treated in our hospital from February 2016 to February 2019 were selected as the research subjects. They were divided into the observation group （n=37） and the control group （n=37） according to the random number table method. Basic periodontal treatment was used in the control group. In the observation group， Probiotics Buccal Tablets combined with basic periodontal treatment was adopted. The salivary interleukin-6， interleukin-10， oral pathogenic flora， matrix metalloproteinase-9 levels and treatment effect were compared in the two groups. Results The levels of salivary interleukin-6 and matrix metalloproteinase-9 in the observation group were lower than those in the control group， the differences were statistically significant （P<0.05）. The level of interleukin-10 in the observation group was higher than that in the control group， and the difference was statistically significant （P<0.05）. The oral pathogenic bacteria in the observation group were lower than those in the control group， and the differences were statistically significant （P<0.05）. The total effectiveness rate of clinical treatment in the observation group was higher than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion In patients with chronic periodontitis accompanied by bad breath， the use of Probiotics Buccal Tablets combined with periodontal basic treatment can effectively reduce the levels of interleukin-6 and matrix metalloproteinase-9， increase interleukin-10 level， and improve oral pathogenic flora. It can obtain a favorable clinical treatment effect， with certain application value， and should be widely used in the clinic.

[Key words] Probiotics Buccal Tablets; Basic periodontal treatment; Chronic periodontitis; Bad breath; Oral microecology

慢性牙周炎是一种局部因素引起的口腔慢性炎症，发病年龄多在35周岁以上，一般病症最早发生在牙龈，牙龈炎症在发病时如果不能及时有效地进行治疗，炎症会随着病症的加重逐渐向牙槽骨、牙周膜和牙骨质发展，成为牙周炎，牙周炎在病症较重时，患者的牙齿会不能保留，因此在病症早期，医疗人员在进行诊治的过程中需要明确地告知患者这一状况，提醒患者在病症早期进行治疗[1-2]。相关的临床研究表明，慢性牙周炎的主要致病因素为牙菌斑[3]。国内研究表明，牙菌斑是黏附于牙齿表面的微生物菌群，日常漱口与冲洗不能有效地进行清除，在口腔中会影响口腔微生态，使致病菌群显著增高，引起牙龈炎症，逐渐转变为牙周炎，影响患者的口腔健康[3-5]。……