磁共振多序列联合检查对早产儿脑损伤早期诊断的临床意义
2020-03-28于鹏
于鹏
摘要:目的:磁共振(MRI)多序列联合检查对早产儿脑损伤早期诊断的临床意义。方法:选取本院新生儿重症监护室于2016年1月-2019年1月收治的86例早产儿,均行头颅MRI多序列联合检查,观察其影像表现。结果:早产儿脑损伤最为多见的是缺血性病灶,脑蛋白损伤最为常见,特别是脑室周围白质软化。缺血性脑损伤主要表现有T2加权成像(T2WI)低信号、侧脑室周围斑片T1加权成像(T1WI)、弥散加权成像(DWI)序列呈现为显著高信号。DWI对缺血灶检出率较常规扫描明显偏高(P<0.05)。结论:在早产儿脑损伤早期诊断中采用MRI多序列联合检查,能够提供准确的影像学资料,便于诊治工作的开展。
关键词:磁共振;早产儿;脑损伤
中图分类号:R445.2;R651.1+5文献标识码:BDOI:10?郾3969/j.issn.1001-0270.2020.02.06
Abstract: Objective: To investigate the clinical significance of magnetic resonance imaging(MRI) multi-sequence combined examination for early diagnosis of brain injury in premature infants. Methods: 86 cases of premature infants admitted to the neonatal intensive care unit of our hospital from January 2016 to January 2019 were examined by multi-sequence cranial MRI, and their imaging manifestations were observed. Results: Ischemic lesions were the most common brain injury in premature infants, and brain protein injury was the most common, especially periventricular leukomalacia. The main manifestations of ischemic brain injury were low signal on T2-weighted imaging(T2WI), high signal on T1-weighted imaging(T1WI) and diffusion weigh imaging(DWI) sequences of periventricular plaques. The detection rate of ischemic lesions by DWI was significantly higher than that by routine scanning(P<0.05). Conclusion: In the early diagnosis of brain injury in premature infants, MRI multi-sequence combined examination can provide accurate imaging data and facilitate the development of diagnosis and treatment.
Key Words: Magnetic Resonance Imaging; Premature Infants; Brain Injury
近年,伴隨新生儿重症监护治疗技术的持续更新与完善,早产儿存活率持续升高,但针对神经系统损伤而言,其发生数同样随之而快速增加。因早产儿的神经系统还没有完全发育,当其发生脑损伤时,特异临床表现缺乏,至此,脑功能检查和(或)影像学检查便成为了确诊的重要依据[1]。本文针对本院收治的早产儿,行磁共振(MRI)多序列联合检查,分析其影像学特点,提高早期诊断率,现报道如下。
1 资料与方法
1.1 临床资料
在2016年1月-2019年1月这一阶段内,选取本院新生儿重症监护室收治的86例早产儿,胎龄<37周,有原始反射异常、肌张力低下及反应低下等症状。排除中枢神经系统感染、胆红素脑病、低血糖尿病等。其中,男52例,女34例,胎龄区间28+3-36+5周,出生时体重区间1.4-3.1kg,平均(2.0±0.36)kg。
1.2 方法
全部患者均在出生后1-14d内,采用GE1.5t以及3.0t超导MRI成像仪开展检查,头颅正交线圈,均开展弥散加权成像(DWI)、常规MRI及磁敏感加权成像(SWI)扫描。SWI扫描参数:层厚为1.2mm,TE20ms,TR28ms;DWI扫描参数:层厚5mm,TE72ms,TR4600ms,层间距1mm。T1WI扫描参数:层厚5mm,TE13ms,TR500ms。T2WI扫描参数:层厚5mm,TE103ms,TR6000ms。把扫描所得到的SWI原始数据向工作站传输,重建后,进行处理,从中得到最小密度投影图像。……
