邓晖 鲁明 杨熙 秦宏智

[摘要]由于具有取材便捷，创伤较小，生物相容性良好、可塑性良好等优点，自体脂肪移植已成为应用最为广泛的整形美容和修复重建技术之一。但是自体脂肪颗粒移植也存在较多不足，例如脂肪细胞容易被吸收，成活率较低等，而移植脂肪的纯化处理方法是影响脂肪细胞移植成活率的关键因素之一。笔者参与了许多应用自体脂肪颗粒移植进行面部年轻化治疗的手术，现对自体脂肪颗粒的处理方法及其在面部年轻化治疗中的研究进展进行综述。

[关键词]自体脂肪移植;面部年轻化;脂肪颗粒;脂肪纯化

[中图分类号]R622+.9    [文献标志码]A    [文章编号]1008-6455（2020）01-0158-04

Research Progress in Processing Method of Autologous Fat Granule and Its Application in Facial Rejuvenation

DENG Hui1，LU Ming2，YANG Xi3，QING Hong-zhi3

（1.Department of Plastic Surgery，Dalian Medical University，Dalian 116000，Liaoning，China; 2.Department of Orthopaedics，the First Affiliated Hospital of Dalian Medical University，Dalian 116000，Liaoning，China;3.Department of Plastic Surgery，the First Affiliated Hospital of Dalian Medical University，Dalian 116000，Liaoning，China）

Abstract： Autologous fat transplantation has become one of the most widely used plastic surgery and reconstructive techniques due to its advantages of easy access to materials， less trauma， good biocompatibility and plasticity. However， autologous fat granule transplantation also has many deficiencies， for example， fat cells are easy to be absorbed and the survival rate is low， and the purification of fat transplantation is one of the key factors affecting the survival rate of fat cell transplantation. The author has participated in many operations of facial rejuvenation using autologous fat granule transplantation. This article reviews the the research progress of processing method of autologous fat granule and tts application in facial rejuvenation.

Key words： autologous fat transplantation; facial rejuvenation; fat granule; purification of fat

隨着社会和医学的发展进步，人们对面部年轻化的要求也日益提高。针对于随年龄增长出现的面部凹陷，目前组织充填与年轻化的治疗多以手术和注射为主，所采用的材料也较多，如：透明质酸、聚四氟乙烯膨体、硅胶假体及自体脂肪等[1]。透明质酸注射后机体代谢快，通常只能保持9～12个月，需患者持续注射以维持效果。面部放置假体可能使机体出现排异反应，内置物引起的各种不良反应，患者对假体的不适感，外观不够自然等缺点。自体脂肪是整形外科进行软组织填充和塑形的常用填充材料，具有取材简单、操作快捷及塑形好等优点。目前，自体脂肪移植已成为应用最为广泛的整形美容和修复重建技术之一[2]。由于整形医生的个人经验和学术论点各有不同，他们对于自体脂肪的处理方法也有所差异。……