郭志锋 李文斌 曾育林

摘要：目的 探討肤康舒方治疗老年性皮肤瘙痒症的临床疗效并评估其药物安全性。方法 将本院门诊就诊的62例老年性皮肤瘙痒症患者按随机数字表的方式分为对照组与观察组各31例，其中对照组予每日1次口服西替利嗪，观察组予每日1次沐浴时外用肤康舒方，4周后对比2组的临床疗效，症状、体征积分，皮肤病生活质量指数评分（DLQI），药物不良反应事件。结果 治疗后，组间对比，观察组总有效率显著高于对照组，差异具有统计学意义（P<0.05）。治疗后，组内对比，2组瘙痒程度、瘙痒面积、继发皮损评分均较治疗前降低，差异具有统计学意义（P<0.05）;组间对比，观察组瘙痒程度、瘙痒面积、继发皮损评分降低明显，差异具有统计学意义（P<0.05）。治疗后，组内对比，2组DLQI评分均较治疗前降低;组间对比，观察组DLQI评分降低明显，差异具有统计学意义（P<0.05）。治疗后，观察组药物不良反应事件发生率为0.00%，明显低于对照组（9.68%），差异具有统计学意义（P<0.05）。结论 肤康舒方治疗老年性皮肤瘙痒症具有明显的疗效，可明显缓解瘙痒，提高皮肤病患者生活质量，且安全可靠，适合在岭南地区进一步推广应用。

关键词：肤康舒方;老年性皮肤瘙痒症;疗效观察

中图分类号：R751   文献标志码：B   文章编号：1007-2349（2019）08-0044-03

【Abstract】Objective： To study the clinical effect of Fukangshu prescription in the treatment of senile pruritus and to evaluate its drug safety. Methods： 62 patients with senile pruritus from the outpatient department of our hospital were randomly divided into a control group and an observation group， 31 cases per group. The control group was given oral cetirizine once a day and the observation group was given external Fukangshu prescription in shower once a day. The clinical effects， symptoms and signs scores， skin disease of life quality index score （DLQI）， and adverse drug reaction events of the two groups were compared after 4 weeks. Results： After treatment， the total effective rate of the observation group was significantly higher than that of the control group， and the difference was statistically significant （P<0.05）. After treatment， the comparison between the intra-groups showed the degree of pruritus， pruritus area， and secondary skin lesion scores were lower than those of the pre-treatment， and the difference was statistically significant （P<0.05）. After treatment， the comparison between the inter-groups showed the degree of pruritus， pruritus area， secondary skin lesion scores decreased significantly， and the difference was statistically significant （P<0.05）. After treatment， in the intragroup comparison， DLQI scores of the two groups were lower than that of the pre-treatment， and in the intergroup comparison， DLQI score of the observation group decreased significantly， and the difference was statistically significant （P<0.05）. After treatment， the incidence of adverse drug reactions in the observation group was 0.00%， significantly lower than that in the control group （9.68%）， and the difference was statistically significant （P<0.05）. Conclusion： Fukangshu prescription has obvious therapeutic effect on senile pruritus and can relieve itching and improve the quality of life of patients with skin diseases. It is safe and reliable and suitable for further application in Lingnan area.

【Key words】Fukangshufang prescription， senile pruritus， therapeutic effect

老年性皮膚瘙痒症是老年人常见的皮肤病，表现为无原发性皮损的全身或局部皮肤阵发性瘙痒[1]。多数患者因长期反复的搔抓动作，造成一系列的健康问题，严重降低患者的生活质量[2]。老年性皮肤瘙痒症通常病因复杂，多数西医学者认为与老年人皮肤退行性萎缩、皮脂功能减退、皮肤局部血液循环欠佳、周围血管病变、内环境紊乱等相关[3-4]，治疗颇为棘手，多以口服抗组胺药物如西替利嗪等、外用糖皮质激素等对症处理，然而上述用药远期疗效不确定，且伴随如激素依赖，皮肤萎缩，嗜睡等药物不良反应事件[5]。故寻找可有效改善临床症状的治疗方法意义重大，获益深远。老年性皮肤瘙痒症在中医辨病为“风瘙痒”[6]，不同的学家看法不同，如有学者认为瘙痒多因风、湿、热等邪客肤表所致;脾主肌肉，肌肤疾患多与脾相关;老年患者肝肾不足，气血亏虚，肌肤不营而发为痒症等[5-7]。……