孙广升　王燕

[摘要] 目的 探討阿托伐他汀钙对改善慢性硬膜下血肿出血量及神经功能的价值。方法 便利收集2017年3月—2018年4月该院100例慢性硬膜下血肿的患者，两组患者入院后给予营养神经、改善微循环、对症治疗。研究组在上述治疗上口服阿托伐他汀钙片。对比两组治疗前后慢性硬膜下血肿出血量;两组治疗前后神经功能;两组治疗前后体内炎症因子水平。结果 研究组和对照组治疗前慢性硬膜下血肿出血量分别为[（74.25±16.71）mL、（75.16±17.44）mL]，差异无统计学意义（t=0.355，P>0.05）; 研究组和对照组治疗后慢性硬膜下血肿出血量分别为[（23.26±7.23）mL、（53.15±8.96）mL]，差异有统计学意义（t=6.332，P<0.05）;研究组和对照组治疗前中国卒中量表分别为[（22.36±3.27）分、（22.09±4.02）分]差异无统计学意义（t=0.147，P>0.05）; 研究组和对照组治疗后中国卒中量表分别为[（12.85±1.98）分、（14.28±2.05）分]差异有统计学意义（t=5.287，P<0.05）。研究组手术后1 d及手术后3 dTNF-β及IL-4炎症因子指标均低于对照组，两组分别为[（39.62±5.14）ng/L、（56.24±15.34）ng/L、（5.42±1.18）ng/L、（12.16±1.87）ng/L]、[（59.14±5.22）ng/L、（7.96±3.37）ng/L、（65.97±16.02）ng/L、（23.64±2.26）ng/L]，差异有统计学意义（P<0.05）。结论 阿托伐他汀钙能够明显减少慢性硬膜下血肿患者的出血量，同时对提高神经功能有重要价值。

[关键词] 阿托伐他汀钙;慢性硬膜下血肿;出血量;神经功能

[中图分类号] R651          [文献标识码] A          [文章编号] 1674-0742（2019）05（b）-0023-03

[Abstract] Objective To investigate the value of atorvastatin calcium in improving the amount of hemorrhage and neurological function in chronic subdural hematoma. Methods 100 patients with chronic subdural hematoma in our hospital from March 2017 to April 2018 were convenient selected and enrolled. The patients in the two groups were given nutritional nerves， improved microcirculation and symptomatic treatment after admission. The study group took oral atorvastatin calcium tablets on the above treatment. The amount of chronic subdural hematoma bleeding before and after treatment was compared between the two groups; as well as the neurological function before and after treatment; the levels of inflammatory factors in the two groups before and after treatment. Results The blood loss of chronic subdural hematoma in the study group and the control group was [（74.25±16.71）mL，（75.16±17.44）mL]， the difference was not statistically significant （t=0.355， P>0.05）. The study group and the control group after the treatment of the amount of post-chronic subdural hematoma was [（23.26±7.23）mL， （53.15±8.96）mL]， the difference was statistically significant （t=6.332， P<0.05）. The Chinese stroke scales of the study group and the control group were[（22.36±3.27）points， 22.09±4.02）points]. The difference was not statistically significant （t=0.147， P>0.05）. The Chinese stroke scales of the study group and the control group were[（12.85±1.98）points，（14.28±2.05）points]. The difference was statistically significant （t=5.287， P<0.05）. The TNF-β and IL-4 inflammatory factors were lower in the study group than in the control group 1 day after surgery and 3 days after surgery. The two groups were [（39.62±5.14）ng/L， （56.24±15.34）ng/L，（5.42±1.18）ng/L， （12.16±1.87）ng/L]， [（59.14±5.22）ng/L， （7.96±3.37）ng/L， （65.97±16.02）ng/L， （23.64±2.26）ng/L]， the difference was statistically significant （P<0.05）. Conclusion Atorvastatin calcium can significantly reduce the amount of bleeding in patients with chronic subdural hematoma， and it is of great value in improving nerve function.

[Key words] Atorvastatin calcium; Chronic subdural hematoma; Amount of bleeding; Neurological function

慢性硬膜下血肿是指颅脑损伤后血液积聚于硬脑膜下腔3周以上出现的相关临床症状，一般血肿量可达100～300 mL[1]。相关研究[2-5]指出阿托伐他汀钙可以促进血肿的吸收，改善压迫脑组织的神经功能。为此该文便利收集2017年3月—2018年4月该院100例慢性硬膜下血肿的患者，分析阿托伐他汀钙的治疗价值，现报道如下。

1  资料与方法

1.1  一般资料

便利收集该院100例慢性硬膜下血肿的患者，所有患者通过颅脑CT确诊，同时有明确的脑部外伤史。随机分为2组，50例研究组和50例对照组，研究组男、女分别为27例、23例，平均年龄（49.35±15.05）岁，对照组男、女分别为25例、25例，平均年龄（50.74±16.31）岁。两组患者知情同意，研究获得医院伦理委员会批注。