谢建培

[摘要] 目的 分析研讨血清C肽联合糖化血红蛋白检验诊断糖尿病的临床作用。 方法 方便抽取该院2016年4月—2018年5月收治的糖尿病患者76例（研究组），另从该院同时期体检健康者中抽取76名作为对照组，均接受血清C肽和糖化血红蛋白检验，分析比较诊断作用。 结果 研究组餐后2 h血糖（9.58±2.18）mmol/L、空腹血糖（9.58±2.18）mmol/L、血清C肽（0.88±0.08）μg/L、糖化血红蛋白（11.76±0.36）%均高于对照组餐后2 h血糖（4.21±0.68）mmol/L、空腹血糖（4.69±1.42）mmol/L、血清C肽（1.29±0.67）μg/L、糖化血红蛋白（5.01±0.69）%，组间数据差异有统计学意义（t=20.500 4、24.093 1、5.297 1、75.610 4，P=0.000 0、0.000 0、0.000 0、0.000 0）。 结论 联合检测血清C肽与糖化血红蛋白对诊断糖尿病有积极意义，可降低疾病漏诊率，提升诊断准确性，值得推广。

[关键词] 糖尿病;血清C肽;糖化血红蛋白;诊断;检验

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1674-0742（2019）05（a）-0196-03

[Abstract] Objective To analyze and discuss the clinical effect of serum C-peptide combined with glycosylated hemoglobin detection in diagnosis of diabetes mellitus. Methods Convenient select a total of 76 cases of patients with diabetes mellitus and who treated in our hospital from April 2016 to May 2018 were randomly selected for discussion （study group）. Other 76 cases of healthy persons who had physical examination in the same period in our hospital were selected as control group. All patients were received the serum C-peptide combined with glycosylated hemoglobin detection. Then， the diagnostic effects were analyzed and compared. Results In the study group， the postprandial 2 h blood sugar was （9.58±2.18） mmol/L， fasting blood glucose was （9.58±2.18）mmol/L， serum C-peptide was （0.88±0.08）μg/L and glycosylated hemoglobin was （11.76±0.36）%， which were higher than those in the control group （4.21±0.68）mmol/L， （4.69±1.42） mmol/L， （1.29 ±0.67）μg/L， （5.01±0.69）%， and there was significant differences between groups （t=20.500 4， 24.0931， 5.297 1， 75.610 4， P=0.000 0， 0.000 0， 0.000 0，0.000 0）. Conclusion The combined detection of serum C-peptide and glycosylated hemoglobin has positive significance in diagnosis of diabetes mellitus， which can reduce the rate of missed diagnosis and improve the accuracy of diagnosis， thus it is worth promoting.

[Key words] Diabetes mellitus; Serum C-peptide; Glycosylated hemoglobin; Diagnosis; Detection

糖尿病中老年人群常見临慢性内分泌疾病[1]。病症将导致机体血糖水平异常，使其血糖长期处于高水平状态，若长时间未得到有效控制，可能引发其他并发症，严重影响健康。目前主要测定空腹血糖水平及口服葡萄糖耐量方式诊断糖尿病，但此指标均无法准确判定糖尿病病情程度。血清C肽可反映出胰岛素分泌和合成状况，而糖化血红蛋白合成较为稳定，不受血糖波动影响，而血清C肽和糖化血红蛋白指标在诊断糖尿病中有独特性作用。为此，2016年4月—2018年5月该院为探讨其在糖尿病诊断中实际价值，现报道如下。

1  资料与方法

1.1  一般资料

于该院收治的糖尿病患者中方便抽取76例为研究组，取同时期体检健康者76名为对照组。患者均满足《2010美国糖尿病协会糖尿病治疗指南》[2]中糖尿病诊断标准;患者与家属均知晓同意该研究;患者病历资料均齐全。……