李文玉

【摘要】 目的：探究妊娠期高血压疾病患者应用甲基多巴联合硝苯地平治疗的效果。方法：将2017年1月-2018年12月笔者所在医院收治的84例妊娠期高血压疾病的患者纳入研究范围，并应用随机数字表法进行平均分组，试验组应用甲基多巴联合硝苯地平进治疗，对照组单纯甲基多巴治疗，对比临床治疗效果。结果：试验组患者治疗的总有效率显著高于对照组，且试验组患者新生儿窒息、胎盘早剥、产后出血及胎儿宫内窘迫等不良分娩结局发生率显著低于对照组，差异均有统计学意义（P<0.05）。结论：采用甲基多巴联合硝苯地平对妊娠期高血压疾病患者进行干预，有利于稳定患者的血压水平，降低不良分娩情况的发生率。

【关键词】 妊娠期高血压疾病; 甲基多巴; 硝苯地平

doi：10.14033/j.cnki.cfmr.2019.28.067 文献标识码 B 文章编号 1674-6805（2019）28-0-02

Effect of Methyldopa Combined Nifedipine in 42 Cases of Hypertensive Disorder Complicating Pregnancy/LI Wenyu. //Chinese and Foreign Medical Research， 2019， 17 （28）： -159

[Abstract] Objective： To explore the effect of Methyldopa and Nifedipine on patients with hypertensive disorder complicating pregnancy. Method： A total of 84 patients with hypertensive disorder complicating pregnancy in our hospital from January 2017 to December 2018 were enrolled in the study. The patients were divided into two groups by means of random number table. The experimental group treated by Methyldopa combined with Nifedipine and the control group by Methyldopa alone.The clinical effects were compared between the two groups. Result： The total effective rate of the experimental group was significantly higher than that of the control group， and the incidence of adverse delivery outcomes such as neonatal asphyxia， placental abruption， postpartum hemorrhage and fetal distress in the experimental group was significantly lower than that in the control group， the differences were statistically significant （P<0.05）. Conclusion： The intervention of Methyldopa combined with Nifedipine in patients with hypertensive disorder complicating pregnancy is helpful to stabilize the blood pressure level of patients and reduce the incidence of adverse delivery outcomes.

[Key words] Hypertensive disorder complicating pregnancy Methyldopa Nifedipine

First-authors address： Zaoyang Maternal and Child Health Hospital， Zaoyang 441200， China

妊娠期高血壓疾病是当前临床领域多发的疾病，其主要包括妊娠期高血压、慢性高血压、子痫前期、子痫及子痫前期并慢性高血压等病症，其患病因素大多与遗传、免疫适应不良、胎盘缺血及氧化应激学说等多种因素相关，患者患病后大都会在妊娠20周后出现血压升高、蛋白尿和水肿病症[1]，若是病症较轻，患者不会出现明显的症状，血压仅轻微升高，出现水肿会轻度的蛋白尿，若是病情较为严重，患者经常会出现头晕眼花、头部疼痛、恶心呕吐及右上腹部疼痛病症，患者的尿蛋白量会逐渐增加，水肿也会愈发明显[2]，严重时甚至会出现昏迷或者抽搐现象，为了保证母婴的健康安全，必须及时采取措施对患者病症进行治疗干预，所以本试验对42例妊娠期高血压疾病患者应用甲基多巴联合硝苯地平治疗的效果进行分析论述，现报告如下。……