张小月

【摘要】 目的：探討子宫内膜异位症患者血清肿瘤相关抗原125（CA125）水平及与临床病理参数的相关性。方法：选择2014年2月-2018年12月在笔者所在医院行手术治疗的82例子宫内膜异位症患者为研究组，选择同期就诊于笔者所在医院的60例卵巢囊肿患者为卵巢囊肿组，28例子宫腺肌症患者为子宫腺肌症组。检测三组血清CA125水平与阳性率，分析血清CA125水平与子宫内膜异位症患者临床病理参数的相关性。结果：与卵巢囊肿组相比，研究组与子宫腺肌症组血清CA125水平及阳性率均较高，差异有统计学意义（P<0.05），研究组血清CA125水平及阳性率高于子宫腺肌症组，但两组比较差异无统计学意义（P>0.05）。不同病理类型、r-AFS分期子宫内膜异位症患者血清CA125水平比较，差异有统计学意义（P<0.05）。子宫内膜异位症患者血清CA125水平与病理类型、r-AFS分期有明显的相关性（r=0.369、0.521，P=0.000）。结论：血清CA125水平可用做鉴别子宫内膜异位症患者的病理类型、r-AFS分期的有效指标，但早期诊断子宫内膜异位症敏感性欠佳，可辅助临床鉴别诊断卵巢囊肿。

【关键词】 子宫内膜异位症 肿瘤相关抗原125 临床病理参数

doi：10.14033/j.cnki.cfmr.2019.28.025 文献标识码 B 文章编号 1674-6805（2019）28-00-03

The Correlation between Serum CA125 Level and Clinical Pathological Parameters in Patients with Endometriosis/ZHANG Xiaoyue. //Chinese and Foreign Medical Research， 2019， 17（28）： -63

[Abstract] Objective： To investigate the correlation between serum tumor associated antigen 125 （CA125） level and clinical pathological parameters in patients with endometriosis. Method： A total of 82 patients with endometriosis who underwent surgery treatment in our hospital from February 2014 to December 2018 were selected as the study group. A total of 60 patients with ovarian cysts who were admitted in our hospital during the same period were selected as the ovarian cyst group， and 28 cases of patients with adenomyosis were selected as the adenomyosis group. The level of serum CA125 and positive rates were detected in the three groups， and the correlation between serum CA125 level and clinicopathological parameters of patients with endometriosis was analyzed. Result： Compared with the ovarian cyst group， the serum CA125 level and positive rate in the study group and the adenomyosis group were both higher， the differences were statistically significant （P<0.05）. The serum CA125 level and positive rate in the study group were higher than that of the adenomyosis group， but there was no significant difference between the two groups （P>0.05）. There were significant differences in serum CA125 level among different pathological types and r-AFS stages of endometriosis （P<0.05）. The difference was statistically significant （P<0.05）. Serum CA125 level in patients with endometriosis was significantly correlated with pathological type and r-AFS stage （r=0.369， 0.521， P=0.000）. Conclusion： Serum CA125 level can be used as an effective index to identify the pathological type and r-AFS stage of patients with endometriosis， but the sensitivity of early diagnosis of endometriosis is not good， which can assist the clinical diagnosis of ovarian cysts.

[Key words] Endometriosis Tumor associated antigen 125 Clinical pathological parameters

First-authors address： Dongtai Traditional Chinese Medicine Hospital， Dongtai 224200， China

子宫内膜异位症属于育龄期女性常见疾病之一，发病率为10%～15%，临床表现为月经异常、痛经、盆腔包快、不孕等[1]。病理学诊断、腹腔镜、磁共振、B超等是临床诊断子宫内膜异位症的常用方式，但病理学诊断、腹腔镜检查具有创伤性;磁共振检查费用昂贵;B超检查缺乏特异性等，均存在一定的局限性[2-3]。血清CA125属于糖蛋白，与卵巢癌密切相关，临床常将其作为诊断子宫内膜异位症的辅助血清学监测指标[4]。本研究选择2014年2月-2018年12月在笔者所在医院行手术治疗的82例子宫内膜异位症患者、60例卵巢囊肿患者、28例子宫腺肌症患者为研究对象，旨在分析子宫内膜异位症患者血清CA125水平及与临床病理參数的相关性，现报告如下。

1 资料与方法