刘晓霞 柯忠妹 甘丰妹 施春芳 叶慧萍 姚小燕

[摘要] 目的 探討中药补肾填精养血治疗对卵巢储备功能恢复的影响。 方法 选取2018年1～10月收治的32例卵巢储备功能下降者，给予中药补肾填精养血治疗，对比患者治疗前后临床症状变化、月经情况、血清激素水平等指标。 结果 ①治疗后，痊愈11例，显效15例，有效1例，总有效率为84.4%;②治疗后，患者H区雌二醇（231.5±52.3）pmol/L、促黄体生成素（43.2±5.6）U/L、卵泡刺激素（65.3±20.1）U/L，L区雌二醇（306.4±102.1）pmol/L、促黄体生成素（19.3±2.7）U/L以及卵泡刺激素（34.2±2.3）U/L均显著优于治疗前水平（P<0.05）;③治疗后，患者子宫体积（25.9±0.6）cm3、卵巢平均体积（2.7±0.3）cm3、子宫内膜厚度（0.6±0.2）cm显著优于治疗前（P<0.05）。④治疗后患者CD4+、CD8+、CD4+/CD8+等指标均显著优于治疗前水平（P<0.05）。⑤治疗后患者心烦易怒、潮热出汗、性交痛、失眠、泌尿系统感染、疲倦乏力等得分显著低于治疗前水平（P<0.05）。 结论 中药补肾填精养血治疗可以有效改善患者卵巢储备功能，调节血清激素水平，值得推广。

[关键词] 中药疗法;补肾填精养血;卵巢储备功能;雌二醇

[中图分类号] R271.9          [文献标识码] B          [文章编号] 1673-9701（2019）32-0127-04

Effect of Chinese medicine reinforcing kidney， replenishing essence， and nourishing blood treatment on recovery of ovarian reserve function

LIU Xiaoxia   KE Zhongmei   GAN Fengmei   SHI Chunfang   YE Huiping   YAO Xiaoyan

Department of Gynecology， Jiaxing Traditional Chinese Medicine Hospital in Zhejiang Province， Jiaxing   314000， China

[Abstract] Objective To explore the effect of Chinese medicine reinforcing kidney， replenishing essence， and nourishing blood treatment on recovery of ovarian reserve function. Methods Thirty-two patients with decreased ovarian reserve function from January to October in 2018 were enrolled in the study and were treated with Chinese medicine reinforcing kidney， replenishing essence， and nourishing blood treatment. The clinical symptoms， menstruation， serum hormone levels and other indicators before and after treatment were compared. Results ①After treatment， 11 cases were cured， 15 cases were markedly effective， 1 case was effective， and the total effective rate was 84.4%. ②After treatment， the H region estradiol was （231.5±52.3） pmol/L， luteinizing hormone was （43.2±5.6） U/L， and follicle stimulating hormone was （65.3±20.1） U/L; the L region estradiol was （306.4±102.1） pmol/L， luteinizing hormone was （19.3±2.7） U/L and follicle stimulating hormone was （34.2±2.3） U/L， which were all significantly better than those before treatment（P<0.05）. ③After treatment， the uterus volume was （25.9±0.6） cm3， the average ovarian volume was （2.7±0.3） cm3， and the endometrial thickness was （0.6±0.2） cm， which were significantly better than those before treatment（P<0.05）. ④CD4+， CD8+， CD4+/CD8+ after treatment were significant better than those before treatment（P<0.05）. ⑤The scores of upset irritability，hot flashes sweating，dyspareunia，insomnia， urinary tract infections，tired weakness after treatment were significant lower than those before treatment（P<0.05）. Conclusion Traditional Chinese medicine reinforcing kidney， replenishing essence， and nourishing blood treatment can effectively improve the patients ovarian reserve function and regulate serum hormone levels， which is worth promoting.

[Key words] Traditional Chinese medicine therapy; Reinforcing kidney， replenishing essence， and nourishing blood; Ovarian reserve function; Estradiol

卵巢储备功能是指卵巢皮质区卵泡成长、发育并形成可受精卵母细胞的能力，主要包括卵泡质量和卵泡数量两个方面[1-2]。卵巢储备功能下降为好发于育龄期女性群体的常见病症，具体表现为卵巢内的卵子质量下降或卵泡数目减少。若不及时干预，有可能导致卵巢功能异常消耗，严重的还会导致卵巢早衰[3-4]。本研究选取2018年1～10月收治的32例卵巢储备功能下降者，探讨中药补肾填精养血治疗对卵巢储备功能恢复的影响，现报道如下。

1 资料与方法

1.1 一般资料

选取2018年1～10月收治的32例卵巢储备功能下降者，纳入标准：①与卵巢储备功能下降临床诊断标准相吻合[5];②年龄低于40岁;③本研究经伦理委员会同意，患者或者家属签署知情同意书。排除标准[6]：①对药物过敏者;②原发闭经与先天生殖器发育异常者;③严重精神疾病及器质性疾病者;④合并严重心肾疾病者。……