傅桥菲　肖秀英　罗云

[摘要] 目的 觀察红花黄色素联合丹参多酚酸盐治疗急性脑梗死的疗效。 方法 将200例脑梗死患者随机分为两组。对照组100例应用红花黄色素，观察组100例在对照组的基础上联用丹参多酚酸盐。治疗14 d后，对两组进行总有效率、LDL-C、HDL-C、TG、TC、全血高切黏度、全血低切黏度、血浆黏度、红细胞比容、大脑中A、大脑前A、大脑后A、基底A、椎A平均血流速度比较。 结果 治疗14 d后，观察组总有效率91.0% ，对照组总有效率77.0%，观察组总有效率显著高于对照组，差异有统计学意义（P<0.05）；两组患者在治疗后LDL-C、HDL-C、TG、TC、全血高切黏度、全血低切黏度、血浆黏度、红细胞比容、大脑中A、大脑前A、大脑后A、基底A、椎A平均血流速度均有所改善，并且观察组与对照组相比，差异有统计学意义（P<0.05）。 结论 红花黄色素联合丹参多酚酸盐治疗急性脑梗死具有较好的临床疗效，具有一定的临床推广应用价值。

[关键词] 红花黄色素；丹参多酚酸盐；急性脑梗死；血脂血液流变学；TCD

[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2018）23-0110-04

Clinical study on safflower yellow combined with salvianolate in the treatment of acute cerebral infarction

FU Qiaofei XIAO Xiuying LUO Yun LIU Xiaohong CHEN Liqun

Department of Pharmacy， Ji'an Central People's Hospital in Jiangxi Province， Ji'an 343000， China

[Abstract] Objective To observe the curative effect of safflower yellow combined with salvianolate on acute cerebral infarction. Methods A total of 200 patients with cerebral infarction were randomly divided into two groups. 100 patients in the control group were treated with safflower yellow， and 100 patients in the observation group were treated with salvianolate on the basis of the treatment of the control group. After 14 days of treatment， total effective rate， LDL-C， HDL-C， TG， TC， whole blood hyperviscosity， whole blood hypoviscosity， plasma viscosity， hematocrit， the average blood flow velocity of middle cerebral artery， anterior cerebral artery， basilar artery and vertebral artery were compared between the two groups. Results After treatment for 14 days， the total effective rate was 91.0% in the observation group and 77.0% in the control group. The total effective rate in the observation group was significantly higher than that in the control group， and the difference was significant（P<0.05）. The LDL-C， HDL-C， TG， TC， whole blood hyperviscosity， whole blood hypoviscosity， plasma viscosity， hematocrit， the average blood flow velocity of middle cerebral artery， anterior cerebral artery， basilar artery and vertebral artery were improved after treatment in both groups， and the difference between the observation group and the control group was statistically significant（P<0.05）. Conclusion Safflower yellow combined with salvianolate has good clinical curative effect in the treatment of acute cerebral infarction， and has certain clinical application value.

[Key words] Safflower yellow； Salvianolate； Acute cerebral infarction； Blood lipid hemorheology； TCD

急性脑梗死又称缺血性脑卒中，主要临床表现为神经功能损伤，其发病原因是脑部血流供应中断或减少，无法及时输送氧气和血液，脑神经细胞缺血缺氧坏死病变。急性脑梗死的发生与血脂升高、血黏度增加、血液流变学改变、大脑血流量下降等因素紧密相关[1]。红花黄色素是从红花中提取出的活性水溶性天然黄色素，其具有良好的药理效应：抗氧化损伤、减少炎症症状、抑制血小板聚集、降低血液黏度和保护脑组织[2，3]。丹参多酚酸盐是从丹参中提取的强效活性成分，其药用功效主要为抑制血栓形成、抗氧化、保护心脑器官和促进受损血管的重生[4，5]。为观察红花黄色素联合丹参多酚酸盐治疗急性脑梗死的临床疗效，本研究选取急性脑梗死患者200例分别给予两种方案治疗，现将研究结果报道如下。……