叶修彬　熊礼生　吴剑

[摘要] 目的 研究探討在前列腺癌的发病机制中缺氧诱导因子-1α（HIF-1α）的作用及其价值。 方法 选择2010年1月～2017年12月期间在我院确诊为前列腺癌患者共51例及良性前列腺增生患者51例，根据患者疾病种类将良性前列腺增生患者分为对照组（n=51）与将前列腺癌患者分为观察组（n=51），采用免疫组化法分别测定比较两组患者的前列腺组织的缺氧诱导因子-1α（HIF-1α）蛋白的表达情况。 结果 观察组（前列腺癌组）患者诱导因子-1α（HIF-1α）蛋白表达阳性率为78.43%，对照组（前列腺增生组）患者诱导因子-1α（HIF-1α）蛋白阳性率为15.69%，可见观察组患者诱导因子-1α（HIF-1α）蛋白阳性率明显高于对照组患者，差异有统计学意义（P<0.05）；同时发现诱导因子-1α（HIF-1α）蛋白与前列腺癌的与Gleason分级及TNM分期及淋巴转移情况呈正比关系（P<0.01）。 结论 缺氧诱导因子-1α（HIF-1α）蛋白在前列腺癌患者表达强烈，并且缺氧诱导因子-1α（HIF-1α）蛋白的过度表达可能与疾病恶性程度正相关，提示预后不良。

[关键词] 缺氧诱导因子-1α（HIF-1α）；前列腺癌；前列腺增生；免疫组化

[中图分类号] R737.25 [文献标识码] A [文章编号] 1673-9701（2018）23-0025-03

The role of hypoxia-inducible factor-1α（HIF-1α） in the pathogenesis of prostate cancer

YE Xiubin1 XIONG Lisheng2 WU Jian1 CHEN Shuhuang1 DU Wei1 ZHANG Shuguang1

1.Department of Urinary Surgery，the Third Affiliated Hospital of Nanchang University， Nanchang 330008，China；2.Department of Urinary Surgery，the First Affiliated Hospital of Nanchang University，Nanchang 330006， China

[Abstract] Objective To investigate the role and value of hypoxia-inducible factor-1α（HIF-1α） in the pathogenesis of prostate cancer. Methods A total of 51 patients diagnosed with prostate cancer and 51 patients with benign prostatic hyperplasia were selected between January 2010 and December 2017 in our hospital. Patients with benign prostatic hyperplasia were divided into control group（n=51） and patients with prostate cancer were divided into observation group（n=51） according to the type of disease. Immunohistochemistry was used to determine the expression of hypoxia-inducible factor-1α（HIF-1α） protein in the prostate tissue of two groups. Results The positive rate of HIF-1α protein in the observation group（prostate cancer group） was 78.43%. The positive rate of HIF-1α protein in the control group （prostatic hyperplasia group） was 15.69%. The positive rate of HIF-1α protein in the observation group was significantly higher than that in the control group， and the difference was statistically significant（P<0.05）； at the same time， it was found that the expression of inducible factor-1α（HIF-1α） protein was positively correlated with Gleason grade， TNM staging and lymph node metastasis of prostate cancer （P<0.01）. Conclusion Hypoxia-inducible factor-1α（HIF-1α） protein is strongly expressed in the patients with prostate cancer， and the overexpression of hypoxia-inducible factor-1α（HIF-1α） protein may be positively correlated with the degree of malignancy of the disease， suggesting a poor prognosis.

[Key words] Hypoxia-inducible factor-1α（HIF-1α）；Prostate cancer；Prostatic hyperplasia；Immunohistochemistry

前列腺癌是我国男性常见的恶性肿瘤，是发生在前列腺上皮的恶性肿瘤。前列腺癌的病因多样，如饮食习惯、遗传因素等[1]。前列腺癌早期临床症状不明显，但随着病情的发展会发生压迫现象等被发现[2]。因此，对于前列腺癌的早期检查十分必要，除了常规检查等，针对于前列腺发病机制，许多引起前列腺癌发生的因素也被列为前列腺癌的一种筛查方法。其中缺氧诱导因子-1α（HIF-1α）被认为是导致前列腺癌十分重要的因素，但致病机制十分复杂[3]。对于缺氧诱导因子-1α（HIF-1α）引起前列腺癌的机制不清，但是对于它在前列腺良恶性疾病的表达的差异是对于前列腺恶性肿瘤的筛查依据。因此本文探讨缺氧诱导因子-1α（HIF-1α）在前列腺癌的发病中的价值及意义，现报道如下。……