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尼莫地平与氟桂利嗪治疗偏头痛合并糖尿病的效果比较

2018-12-10史航

糖尿病新世界 2018年13期
关键词:糖尿病

史航

[摘要] 目的 探讨比较尼莫地平与氟桂利嗪治疗偏头痛合并糖尿病的效果。方法 选取该科2017年2月—2018年2月收治的偏头痛合并糖尿病患者62例,随机分为两组各31例,观察组给予氟桂利嗪治疗,对照组给予尼莫地平治疗,比较效果。结果 观察组总有效率为90.3%,明显优于对照组74.2%(P<0.05);观察组FPG、偏头痛发作次数、持续时间、VAS评分均明显低于对照组(P<0.05)。结论 氟桂利嗪治疗偏头痛合并糖尿病效果明显优于尼莫地平,能明显减少偏头痛发作次数和发作时间,值得应用。

[关键词] 尼莫地平;氟桂利嗪;偏头痛;糖尿病

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062(2018)07(a)-0085-02

Comparison of Effect of Nimodipine and Flunarizine in Treatment of Migraine Combined with Diabetes

SHI Hang

Department of Neurology, Changchun Central Hospital, Changchun, Jilin Province, 130000 China

[Abstract] Objective To study the effect of nimodipine and flunarizine in treatment of migraine combined with diabetes. Methods 62 cases of patients with migraine combined with diabetes admitted and treated in our hospital from February 2017 to February 2018 were selected and randomly divided into two groups with 31 cases in each, the observation group and the control group were respectively treated with flunarizine and nimodipine, and the effect was compared between the two groups. Results The total effective rate in the observation group was obviously better than that in the control group (90.3%vs 74.2%)(P<0.05), and the FPG, migraine attack frequency, duration, VAS score in the observation group were obviously lower than those in the control group(P<0.05). Conclusion The effect of flunarizine in treatment of migraine combined with diabetes is obviously better than that of the nimodipine, which can obviously reduce the migraine attack frequency and attack time, and it is worth application.

[Key words] Nimodipine; Flunarizine; Migraine; Diabetes

偏头痛是一类发作性且常为单侧的搏动性头痛。在美国,偏头痛年发病率为11%,因偏头痛造成的社会经济负担达10~17亿美元[1]。我国也有大量偏头痛患者,据统计[2],我国成年人偏头痛的患病率达9.3%,严重影响了患者工作、学习和生活。糖尿病是诱发偏头痛发作的重要因素,糖尿病长期的高血糖环境,可使滋养神经的小血管发生病变,引起神经细胞缺氧、缺血,影响神经传导功能,加重偏头痛病情。目前對偏头痛的治疗仍以缓解头痛发作症状,减少头痛次数和时间为主。该文对该科2017年2月—2018年2月间采用尼莫地平与氟桂利嗪治疗的62例偏头痛合并糖尿病患者进行对比分析,现报道如下。

1 资料与方法

1.1 一般资料

选取该科收治的偏头痛合并糖尿病患者62例,患者均符合2004年国际头痛协会(IHS)颁布的关于偏头痛和1999年WHO制定的糖尿病的诊断标准。随机将患者分为两组各31例,观察组男10例,女21例,年龄17~73岁,平均(35.7±2.4)岁,病程3个月~6年,平均(2.7±1.1)年,糖尿病病程2~11年,平均(6.5±1.0)年;对照组男12例,女19例,年龄17~70岁,平均(33.4±2.1)岁,病程3个月~5年,平均(2.5±0.8)年,糖尿病病程2~10年,平均(6.1±1.3)年。……

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