盛世发

[摘要] 目的 研究对2型糖尿病并椎-基底动脉脑供血不足患者应用奥扎格雷钠的临床治疗效果。方法 随机2017年1月—2018年1月收治将84例2型糖尿病并椎-基底动脉脑供血不足患者分为对照组、研究组，每组各42例。所有患者均给予止吐、镇静、降糖等基础治疗，对照组同时给予盐酸丁咯地尔治疗，研究组给予奥扎格雷钠治疗。治疗2周，观察两组疗效。结果 研究组血流速度、总有效率均优于对照组，且不良反应发生率明显更低，差异有统计学意义（P<0.05）。结论 2型糖尿病并椎-基底动脉脑供血不足患者应用奥扎格雷钠治疗可显著改善供血不足症状，加快血流速度。

[关键词] 2型糖尿病；脑供血不足；奥扎格雷钠；椎-基底动脉

[中图分类号] R587 [文献标识码] A [文章编号] 1672-4062（2018）07（a）-0081-02

Clinical Study on Sodium Ozagrel in Treatment of Patients with Type 2 Diabetes Combined with Vertebrobasilar Cerebral Insufficiency

SHENG Shi-fa

Department of Neurology， Linyi Luozhuang Central Hospital， Linyi， Shandong Province， 276017 China

[Abstract] Objective To research the clinical effect of sodium ozagrel in treatment of patients with type 2 diabetes combined with vertebrobasilar cerebral insufficiency. Methods 84 cases of patients from January 2017 to January 2018 with type 2 diabetes combined with vertebrobasilar cerebral insufficiency admitted and treated in our hospital were randomly selected and divided into two groups with 42 cases in each， all patients were given the basic therapy such as antiemetic， sedative and hypoglycemic therapy， while the control group were treated with buflomedil hydrochloride， while the research group were treated with sodium ozagrel， for two weeks， and the curative effect was observed. Results The blood flow rate and total effective rate in the research group were better than those in the control group， and the incidence rate of adverse reactions was lower， and the difference was statistically significant（P<0.05）. Conclusion The sodium ozagrel in treatment of patients with type 2 diabetes combined with vertebrobasilar cerebral insufficiency can obviously improve the cerebral insufficiency symptom and accelerate the blood flow rate.

[Key words] Type 2 diabetes； Cerebral insufficiency； Sodium ozagrel； Vertebrobasilar

椎-基底動脉脑供血不足是神经内科常见疾病，好发于老年人群[1]。主要与血压降低、颈椎疾病、糖尿病、微血栓形成等因素有关，患者主要表现为头晕头痛、记忆力减退、耳鸣、健忘、失眠多梦、注意力不集中等症状。糖尿病是引起椎-基底动脉脑供血不足的危险因素，长期高血糖状态对血管、靶器官有明显损伤，加重了病情，增加心脑血管不良事件发生率[2]。所以，在治疗时应在降糖基础上给予抗凝血、抗血小板药物，增加脑部血流量，改善患者的预后[2]。该文选取2017年1月—2018年1月收治，84例患者就奥扎格雷钠对2型糖尿病并椎-基底动脉脑供血不足患者的疗效进行探讨，现报道如下。

1 资料与方法

1.1 一般资料

该院收治的84例2型糖尿病并椎-基底动脉脑供血不足患者，随机分为对照组、研究组，每组各42例。对照组中有男25例，女17例；年龄54～77岁，平均年龄（63.3±2.9）岁；……