张富义 高李华

[摘要] 目的 觀察帕拉米韦氯化钠注射液治疗儿童流行性感冒的临床效果。 方法 收集2018年1～6月的诊断为儿童流行性感冒的患儿40例，将其随机分为治疗组和对照组，每组各20例，治疗组给予帕拉米韦氯化钠注射液治疗，对照组给予磷酸奥司他韦颗粒治疗，观察两组间临床疗效。 结果 治疗组体温降至正常在给药第1、2天有效率分别为80%、100%，体温降至正常时间为（22.8±8.6）h；流感症状缓解率在给药第1、2天分别为60%、90%；症状缓解时间为（32.9±4.8）h；治疗组依从性2 d期为100%，4 d期为95%；总临床有效率为100%。对照组体温降至正常在给药第1、2天有效率分别为20%、50%，至第5天100%；体温降至正常时间为（68.6±10.7）h；流感症状缓解率在给药1、2 d分别为15%、40%、至第5天95%；症状缓解时间为（96.5±12.8）h；治疗组依从性2 d期为100%，4 d期为90%，5 d期为85%；总临床有效率为100%。 结论 帕拉米韦氯化钠注射液与磷酸奥司他韦颗粒在儿童流行性感冒的治疗中均能达100%临床有效，但体温降至正常及症状缓解方面帕拉米韦氯化钠注射液所需治疗时间较短，且治疗依从性较对照组高；所以值得临床推广运用。

[关键词] 帕拉米韦氯化钠注射液；磷酸奥司他韦颗粒；流行性感冒；发热

[中图分类号] R511.7 [文献标识码] B [文章编号] 1673-9701（2018）30-0057-04

[Abstract] Objective To observe the clinical effect of peramivir sodium chloride injection on children with influenza. Methods 40 children diagnosed with childhood influenza from January 2018 to June 2018 were randomly divided into treatment group and control group， with 20 cases in each group. The treatment group was given peramivir sodium chloride injection. The control group was given oseltamivir phosphate granules. The clinical efficacy between the two groups was observed. Results The effective rate of the drug in the treatment group on the first and second days of administration when the body temperature dropped to normal was 80% and 100%， respectively. The time the body temperature dropping to normal needing was（22.8±8.6）h. The flu symptom remission rate was 60% and 90% on the first and second days of administration， respectively. The symptom relief time was（32.9±4.8） h. The treatment compliance in the treatment group after 2 days and 4 days of treatment was 100%， 95%， respectively. The total clinical effective rate was 100%. The effective rate of the drug in the control group on the first， second and fifth days of administration when the body temperature dropped to normal was 20%， 50% and 100%. The time the body temperature dropping to normal needing was （68.6±10.7）h. The symptom relief time was （96.5±12.8）h. The flu symptom remission rate was 15%， 40% and 95% on the first， second and fifth days of administration， respectively. The treatment compliance in the control group after 2 d， 4 d and 5 d of treatment was 100%， 90% and 85% respectively. The total clinical effective rate was 100%. Conclusion Peramivir sodium chloride injection and oseltamivir granules can be 100% clinically effective in the treatment of childhood influenza， but the time of body temperature dropping to normal and the symptoms relief which peramivir sodium chloride required is shorter than that oseltamivir granules required. And the treatment compliance in the treatment group is higher than that of the control group. Therefore， it is worthy of clinical application.

[Key words] Peramivir sodium chloride injection； Oseltamivir phosphate granules； Influenza； Fever

流行性感冒（简称流感）是指由流感病毒引起的一类急性呼吸道传染性疾病，病原体属正粘病毒科，为核糖核酸（RNA）病毒，一般分为甲、乙、丙、丁四型，其中甲型和乙型较为常见，丙型和丁型不多见。人群对流感病毒普遍易感，尤其是儿童，发病率高、进展迅速、易引起扩散、流行，年龄小于5岁儿童较易发展为重症病例。……