林海云 黄永坤 王蔚浩

[摘要]目的 探讨盐酸替罗非班氯化钠注射液联合心血管介入治疗急性心肌梗死的效果。方法 选取2015年6月～2017年12月我院接受治疗的60例急性心肌梗死患者为研究对象，将其随机分为两组，每组30例。对照组采用心血管介入治疗，观察组在对照组基础上增加盐酸替罗非班氯化钠注射液治疗。比较两组的临床效果及短期预后指标。结果 观察组的TIMI血流分级情况优于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者的各项血小板活化功能指标比较，差异无统计学意义（P>0.05），治疗后，观察组患者的CD62P、CD63以及MPA阳性表达率明显优于治疗前和对照组，差异有统计学意义（P<0.05）。观察组患者的再发急性心肌梗死、猝死、恶性心律失常、严重出血事件发生率均明显低于对照组，差异有统计学意义（P<0.05）。结论 盐酸替罗非班氯化钠注射液联合心血管介入治疗急性心肌梗死的临床效果较显著，可降低不良预后的发生率，治疗安全性高，值得推广应用。

[关键词]盐酸替罗非班氯化钠注射液；心血管介入治疗；急性心肌梗死

[中图分类号] R542.2+2 [文献标识码] A [文章编号] 1674-4721（2018）7（a）-0063-03

[Abstract]Objective To investigate the effect of Tirofiban Hydrochloride Sodium Chloride Injection combined with cardiovascular intervention treating acute myocardial infarction.Methods Sixty patients with acute myocardial infarction treated in our hospital from June 2015 to December 2017 were selected as study objects and they were randomly divided into the two groups，and there were 30 patients in each group.The control group was treated with cardiovascular intervention.The observation group was treated with Tirofiban Hydrochloride Sodium Chloride Injection on the basis of the control group.The clinical effect and short-term prognosis indexes between the two groups were compared.Results TIMI blood flow grading in the observation group was better than that of the control group，and the difference was statistically significant （P<0.05）.There was no significant difference between the two groups in the activation of platelet before treatment （P>0.05），after treatment，the CD62P，CD63 and positive expression rate of MPA in the observation group was significantly better than that before treatment and the control group （P<0.05）.The incidence of recurrent acute myocardial infarction，sudden death，malignant arrhythmia，severe bleeding events were significantly lower than those of the control group，and the differences were statistically significant （P<0.05）.Conclusion The clinical effect of Tirofiban Hydrochloride Sodium Chloride Injection combined with cardiovascular intervention treating acute myocardial infarction is more significant，which can reduce the incidence of adverse prognosis，which has high safety and is worth popularizing and applying.

[Key words]Tirofiban Hydrochloride and Sodium Chloride Injection；Cardiovascular intervention treatment；Acute myocardial infarction

急性心肌梗死是臨床常见的心血管疾病，多数患者病情危急、病情重，且病情进展快，危及患者的生命健康。急性心肌梗死可引发血小板血栓，致使冠状动脉闭塞，影响血流畅通[1-2]。因此，对于急性心肌梗死的治疗，目前临床主要以抗血小板聚集为主要治疗方法，传统的治疗方法和急诊经皮冠状动脉介入治疗术的效果均不理想，支架内血栓发生率较高。本研究以60例急性心肌梗死患者为研究对象，评价盐酸替罗非班氯化钠注射液联合心血管介入的治疗效果。

1资料与方法

1.1一般资料

选取2015年6月～2017年12月在我院接受治疗的60例急性心肌梗死患者为研究对象，将其随机分为两组，每组30例。对照组中，男16例，女14例；年龄为42～76岁，平均（60.26±3.28）岁；发病至就诊时间为1～9 h，平均（4.05±1.18）h。……