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血清AFP、CA19—9、CEA单项及三者联合检验对原发性肝癌早期诊断及治疗的价值对比评价

2018-10-31苏英弟

中外医疗 2018年17期
关键词:肝癌血清检测

苏英弟

[摘要] 目的 探讨对原发性肝癌患者实施血清AFP、CA19-9、CEA单项及三者联合检验的早期诊断及治疗价值。 方法 方便选择该院2015年10月—2017年10月间收治的60例肝癌患者(肝癌组)及60名健康体检人员(健康组),对所有人员实施血清AFP、CA19-9、CEA检测,分析两组人员检测结果。结果 肝癌组患者AFP(321.5±38.7)μg/L、CA19-9(121.4±32.9)kU/L、CEA(20.8±4.5)μg/L较健康组(7.4±4.8)μg/L、(20.1±10.2)kU/L、(2.3±1.2)μg/L升高(P=0.000、0.000、0.000)。肝癌组患者AFP、CA19-9、CEA单独检测及联合检测阳性率63.3%、60.0%、71.7%、93.3%較健康组13.3%、25.0%、23.3%、38.3%均升高(P=0.000、0.000、0.000、0.000)。两组人员联合检测阳性率均高于单独检查。 结论 原发性肝癌实施血清AFP、CA19-9、CEA三者联合检验可便于患者早期诊断及治疗。

[关键词] 原发性肝癌;AFP;CA19-9;CEA;单项;三者联合

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742(2018)06(b)-0023-03

Evaluation on Comparison of Value of Single Serum AFP, CA19-9, CEA and the Combination of the Three in Early Diagnosis and Treatment of Primary Liver Cancer

SU Ying-di

Department of Clinical Laboratory, Second Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi, 545006 China

[Abstract] Objective To study the comparison of value of single serum AFP, CA19-9, CEA and the combination of the three in early diagnosis and treatment of primary liver cancer. Methods 60 cases of patients with liver cancer and 60 cases of healthy physical examination staff in our department from October 2015 to October 2017 were convenient selected, and the serum AFP, CA19-9, CEA of all staff were tested, and the test results of the two groups were analyzed. Results The AFP(321.5±38.7) μg/L, CA19-9( 121.4±32.9) kU/L, CEA( 20.8±4.5) μg/L of patients in the liver cancer group increased compared with those in the healthy group (7.4±4.8) μg/L, (20.1±10.2)kU/L, (2.3±1.2)μg/L(P=0.000, 0.000, 0.000), and the positive rates of single test and combined test of AFP, CA19-9, CEA in the liver cancer group increased compared with those in the healthy group (63.3%, 60.0%, 71.7%,93.3% vs 13.3%, 25.0%, 23.3%, 38.3%) (P=0.000, 0.000, 0.000, 0.000), and the positive rate of the combined test of the two groups was higher than that of the single examination. Conclusion The implementation of combined test of serum AFP, CA19-9, CEA in primary liver cancer patients contributes to the early diagnosis and treatment.

[Key words] Primary liver cancer; AFP; CA19-9; CEA; Single; Combination of the three

原发性肝癌是全球高发恶性肿瘤疾病,且原发性肝癌患者已经成为威胁人类生命安全的重要恶性肿瘤疾病,致死率极高。临床研究对于原发性肝癌患者疾病发生机制不明确,研究发现早期诊治对改善原发性肝癌患者预后具有显著效果[1]。但原发性肝癌患者早期症状不明显,诊断难度较大,极易漏诊,延误患者治疗。血清肿瘤标志物检测是目前临床进行肿瘤疾病诊断常用方式。为此,该院对2015年10月—2017年10月间收治的60例肝癌患者及60名健康体检人员均实施了血清AFP、CA19-9、CEA检测,现报道如下。

1 资料与方法

1.1 一般资料

方便选择该院收治的60例肝癌患者(肝癌组)及60名健康体检人员(健康组),肝癌组患者中男女比:34:26;患者年龄跨度24~78岁,中位年龄48.3岁;健康组患者中男女比:33:27;患者年龄跨度24~79岁,中位年龄48.4岁。肝癌组与健康组人员一般基线资料独立样本检测结果符合对比研究标准(P>0.05)。

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