李智文

[摘要]目的 探讨川崎病患儿并发冠状动脉损害的高危因素并作分析。方法 选取2014年10月～2016年10月深圳市光明新区人民医院新生儿科收治川崎病患儿30例作为研究对象，按照患儿有无并发冠状动脉损害作为分组标准，分为对照组（n=23，无并发冠状动脉损害）及研究组（n=7，并发冠状动脉损害）。比较分析两组的相关症状指标及实验室检查指标，以明确该类型疾病并发冠状动脉损害的高危因素。结果 川崎病患儿并发冠状动脉损害的因素包括性别、发热时间、血小板指标、血沉指标、CRP指标、血红蛋白指标等。结论 川崎病患儿并发冠状动脉损害的高危因素主要包括发热持续时间、C-反应蛋白（CRP）、血小板、血沉、血红蛋白等，临床可结合高危因素作预测因子。

[关键词]川崎病；冠状动脉损害；高危因素

[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-4721（2018）5（b）-0085-04

Risk factors for coronary artery lesions in children with Kawasaki disease

LI Zhi-wen

Department of Neonatal，People′s Hospital of Guangming New District in Shenzhen City，Guangdong Province，Shenzhen 518106，China

[Abstract]Qbjective To investigate the coronary artery lesions in Kawasaki disease patients and risk factors analysis.Methods From October 2014 to October 2016，the selection of Guangming District of Shenzhen City People′s Hospital Neonatal from Kawasaki disease 30 cases as the research object，according to the children with or without coronary artery lesions as grouping criteria，were divided into control group （n=23，without coronary artery lesions） and study group（n=7，coronary artery lesions）.A comparative analysis of indicators related symptoms index of the two groups of Kawasaki disease and laboratory，to clear the disease risk factors associated with coronary artery lesion.Results Factors associated with coronary artery disease patients include Kawasaki damage fever time，platelet index，erythrocyte sedimentation rate，CRP index，hemoglobin index etc.Conclusion The risk factors for coronary artery lesions mainly include Kawasaki disease duration of fever，C- reactive protein （CRP），platelet，hemoglobin，erythrocyte sedimentation rate，can be combined with clinical risk factors as predictors.

[Key words]Kawasaki disease；Coronary artery injury；Risk factors

川崎病是属于临床发热性疾病，病因未明。川崎病好发于儿童时期人群，且临床发病率呈持续性上升趋势，已成为现今临床最常见的儿童时期获得性心脏病。川崎病随着疾病持续发展，会并发多种并发症，而最为严重的即冠状动脉损害，部分川崎病并发冠状动脉损害患儿会演变成冠状动脉瘤，个别患者会发生冠状动脉狭窄、冠状动脉血栓，甚至猝死[1]。川崎病并发冠状动脉损害所存在的高危因素各不相同，目前认为，导致川崎病并发冠状动脉损害的多种高危因素并非孤立存在，因此临床判断及处理川崎病并发冠状动脉损害造成困难。……