庞子娟

[摘要]目的 研究血脂與激素受体阴性乳腺癌远处转移的关系以及治疗效果。方法 选择我院2012年7月～2016年9月收治的87例激素受体阴性乳腺癌患者作为研究对象，按照是否发生远处转移分为两组，其中38例非远处转移者作为A组，另49例远处转移者作为B组，收集所有患者资料，观察血脂水平变化情况，探讨血脂与激素受体阴性乳腺癌远处转移的关系以及治疗效果。结果 两组在包块大小、淋巴结转移、高TG血症、高TC血症及高LDL-C血症中差异有统计学意义（P<0.05），将上述有差异资料带入Logistic回归方程计算，发现均属于远处转移的危险因素；且经过治疗后PR组患者TG水平明显比治疗前低，差异有统计学意义（P<0.05）。结论 患者血脂水平与激素受体阴性乳腺癌远处转移有一定关联，采取有效治疗方式可明显缓解血脂水平，血脂变化情况可作为诊断远处转移及治疗效果的重要指标。

[关键词]血脂；远处转移；疗效；激素受体阴性乳腺癌

[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-4721（2018）5（b）-0063-03

Study of the relationship between blood lipid and distant metastasis of hormone receptor negative breast cancer and its therapeutic effect

PANG Zi-juan

Department of Oncology，People′s Hospital of Beihai City，Guangxi Zhuang Autonomous Region，Beihai 536000，China

[Abstract]Objective To study the relationship between blood lipid and distant metastasis of hormone receptor negative breast cancer and its therapeutic effect.Methods A total of 87 patients with hormone receptor-negative breast cancer admitted from July 2012 to September 2016 in our hospital were selected as research subjects.According to distant metastasis or not，they were divided into two groups.Among them，38 patients without distant metastasis were classified into group A，and the remaining 49 cases with distant metastasis were categorized into group B.The complete data in these participants were collected in order to observe the changes in blood lipid levels，and explore the relationship between blood lipids and hormone receptor-negative breast cancer distant metastasis and its therapeutic effect.Results There were significant differences in tumor size，lymph node metastasis，hypertriglyceridemia，hypercholesteremia，and high low-density lipoprotein cholesterol （LDL-C） between the two groups（P<0.05）.The differential data were included in the Logistic regression equation and all of them belonged to risk factors of distant metastasis.After treatment，the triglyceride （TG） level in the PR group was significantly lower than that before treatment with a statistical difference（P<0.05）.Conclusion The level of serum lipids is associated with the distant metastasis of hormone receptor negative breast cancer to some extent.Effective treatment can significantly relieve the blood lipid level and the change of blood lipid level can be used as an important index to diagnose the distant metastasis and the therapeutic effect.

[Key words]Blood lipids；Distant metastasis；Efficacy；Hormone receptor negative breast cancer

乳腺主要是由纤维组织、皮肤以及脂肪组成，乳腺癌属于常见恶性肿瘤，多发于乳腺腺上皮组织。近几年，随着我国社会经济不断发展，人们饮食习惯的改变，导致乳腺癌发病率日趋增长，受到医疗界相关人士广泛关注[1-2]。根据相关报道显示，人们血脂水平与乳腺癌疾病发展有一定关联[3-5]。但关于激素受体阴性乳腺癌患者远处转移相关报道较少，本研究选择我院收治的87例激素受体阴性乳腺癌患者作为研究对象，通过监测治疗前后血脂水平变化情况，探讨血脂与激素受体阴性乳腺癌远处转移的关系以及治疗效果，现报道如下。

1资料与方法

1.1一般资料

选择我院2012年7月～2016年9月收治的87例激素受体阴性乳腺癌患者作为研究对象，均为女性，年龄34～67岁，平均（52.4±3.1）岁。按照是否发生远处转移分为两组，将其中38例非远处转移者作为A组，另49例远处转移者作为B组。……