韩慧

[摘要] 目的 探讨依帕司他辅助治疗早期糖尿病肾病对患者肾功能及氧化应激反应的影响。方法 选择2016年7月—2017年7月到该院进行早期糖尿病肾病治疗的患者200例，将200例患者随机分为两组，并编号为实验组和对照组，对照组患者使用常规治疗，实验组患者在对照组患者常规治疗的基础上，使用依帕司他进行辅助治疗， 对两组患者进行氧化应激反应测评，对患者肾功能进行检测。结果 经过检测，实验组患者肾功能相关指标明显低于对照组，且实验组患者氧化过激相关抗氧化物指标，明显低于对照组。数据对比差异有统计学意义（P<0.05）。结论 使用依帕司他对糖尿病肾病患者进行辅助治疗，患者肾功能较好，且患者氧化过激反应先关抗氧化物指标较高，对患者的治疗更有效。

[关键词] 依帕司他；早期糖尿病肾病；氧化应激反应

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）02（b）-0183-02

Effect of Epalrestat Adjuvant Therapy on Renal Function and Oxidative Stress in Patients with Early Diabetic Nephropathy

HAN Hui

Department of Health Care， Tai'an Traditional Chinese Medicine Hospital， Tai'an， Shandong Province， 271000 China

[Abstract] Objective This paper tries to investigate the effect of epalrestat in the treatment of early diabetic nephropathy on renal function and oxidative stress. Methods A total of 200 patients with early diabetic nephropathy treated in July 2016 to July 2017 were selected. 200 patients were randomly divided into two groups， numbered as experimental group and control group. Patients in the control group were treated with routine treatment. Patients in the experimental group were treated with epalrestat on the basis of routine treatment in the control group. Oxidative stress responses were measured in both groups and renal function was measured. Results After testing， the renal function-related indicators in the experimental group were significantly lower than those in the control group， and the oxidation-related antioxidants in the experimental group were significantly lower than those in the control group. the difference was statistically significant between the data comparision（P<0.05）. Conclusion The use of epalrestat for adjunctive treatment of patients with diabetic nephropathy， the patient's renal function is better， and the patient's treatment is more effective when the patient's oxidative over-reaction is preceded by a higher antioxidant index.

[Key words] Epalrestat； Early diabetic nephropathy； Oxidative stress response

糖尿病腎病时常见代谢合并症的一种，引起该病的原因较多，常见的有血糖因素造成的，以及高血压引发的糖尿病肾病[1]。除了由以上原因造成，个人生活习惯以及生活环境因素，同样有可能造成患者患有糖尿病肾病[2]。对该病及时治疗，能够避免该病的恶化，对患者的身体健康有积极作用[3]。该篇文章选取2016年7月—2017年7月该院收治的200例患者为研究对象，对依帕司他辅助治疗早期糖尿病肾病对患者肾功能及氧化应激反应的影响进行分析，讨论如下。

1 资料与方法

1.1 一般资料

选择到该院进行早期糖尿病肾病治疗的患者200例，将200例患者随机分为两组，并编号为实验组和对照组，每组患者100例。患者的选取设定一定的标准，选取经确诊患有糖尿病肾病的患者，且患者对治疗的药物并无过敏反应，患者身体其他器官无重大疾病，能够坚持接受治疗[4]。……