孟勤凤

[摘要] 目的 探究在糖尿病人全麻诱导期间应用右美托咪定对心率变异性的影响。方法 选取该院2017年1—12月收治的80例糖尿病患者为对象，实验组使用右美托咪定麻醉诱导；对照组用等量生理盐水替代。比对两组麻醉效果。结果 实验组在负荷量结束至插管5 min间HR减缓，MAR降低，与静息时相比差异有统计学意义（P<0.05）；实验组患在插管后1 minHR减缓，负荷量结束时MAP降低，与对照组相比差异有统计学意义（P<0.05）。结论 在糖尿病患者全麻诱导期间应用右美托咪定不会对心率变异性造成显著影响，其影响较小，对于气道插管反应有一定的抑制作用。

[關键词] 右美托咪定；糖尿病患者；全麻诱导期间；心率变异性；影响

[中图分类号] R614 [文献标识码] A [文章编号] 1672-4062（2018）02（b）-0084-02

Effect of Dexmedetomidine on Heart Rate Variability During Induction of General Anesthesia in Diabetic Patients

MENG Qin-feng

Anesthesiology Department， Linyi Mental Health Center， Linyi， Shandong Province， 276005 China

[Abstract] Objective This paper tries to investigate the effect of dexmedetomidine on heart rate variability during general anesthesia induction in diabetic patients. Methods 80 patients with diabetes in this hospital as subjects from January to December 2017 were selected. The experimental group used dexmedetomidine to induce anesthesia； the control group was replaced with the same amount of normal saline. The anesthetic effects of the two groups were compared. Results In the experimental group， the HR slowed down from the end of the loading to 5 minutes after intubation， and the MAR decreased， which was statistically different from that at rest （P<0.05）. The experimental group experienced a slower HR at 1 min after intubation， and decreased MAP at the end of the loading. There was a statistically significant difference compared with the control group （P<0.05）. Conclusion The application of dexmedetomidine during the induction of general anesthesia in patients with diabetes will not have a significant effect on heart rate variability， its effect is small， and it has a certain inhibitory effect on airway intubation.

[Key words] Dexmedetomidine； Diabetics； Induction period during general anesthesia； Heart rate variability； Effect

糖尿病患者具有较高机率并发神经系统、心血管系统等疾病，因此如何有效的抑制全麻诱导期应激反应成为确保糖尿病患者围术期生命体征安全的关键点和重中之重[1]。右美托咪定属于高选择性α2肾上腺素能受体激动剂，其镇痛、镇静、抗交感神经活性及稳定围术期血流变的作用十分显著，成为一种在临床备受关注的药物[2]。但是临床中缺少足够的报道以了解右美托咪定对糖尿病患者心率变异性的影响。该文为探究在糖尿病患者全麻诱导期间应用右美托咪定对心率变异性的影响，于2017年1—12月选取在该院就诊的80例糖尿病患者作为研究对象参与临床研究，取得满意结果。现详细报道如下。

1 资料与方法

1.1 一般资料

选取在该院就诊的80例糖尿病患者作为研究对象参与临床研究，根据抽签结果将患者均分为两组，各40例，实验组中男性患者22例，女性患者18例，平均年龄为（47.29±10.26）岁，对照组中男性患者21例，女性患者19例，平均年龄为（46.94±11.05）岁。两组患者在年龄、性别、病情等方面均差异无统计学意义（P>0.05）。……