依巴代提古丽·艾买提 热依拉·阿布力克木

[摘要] 目的 探讨观察阿卡波糖联合其他降糖药物治疗糖尿病的临床疗效及进展情况。方法 选取2016年5月—2017年12月期間该院收治的180例糖尿病患者，对其进行随机分组，联合治疗组和对照组，各组均为90例患者，其中为对照组患者针对应用各种其他降糖药物治疗，而联合治疗组则在此基础上联合给予阿卡波糖（于每日三餐前口服50～100 mg）治疗，观察对比两组糖尿病患者的临床降糖效果。结果 治疗后，两组患者的空腹血糖和餐后2 h血糖值均较治疗前有明显性下降，但经统计学组间比较，治疗后的联合治疗组患者的降糖效果更优于对照组，差异有统计学意义（P<0.05）。而且在降糖治疗过程中，联合治疗组患者的低血糖发生率及药物用量均明显低于对照组，差异有统计学意义（P<0.05）。结论 阿卡波糖联合其他降糖药物治疗糖尿病的临床疗效更为显著，可明显缩短糖尿病患者的血糖达标时间，有效降低治疗期间发生的低血糖事件，且可降低相关药物的实际用量，具有更高的用药安全性，值得临床中进一步研究其药物联合应用方案及疗效进展。

[关键词] 阿卡波糖；降糖药物；糖尿病

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2018）02（b）-0009-02

The Clinical Efficacy of Acarbose in Combination with Other Antidiabetic Drugs for the Treatment of Diabetes

Ibadatiguri ·Amat，Geira ·Ablickwood

Department of Pharmacy， First People's Hospital， Kashi， Xinjiang，844000 China

[Abstract] Objective To the investigate the clinical efficacy and progress of observation of acarbose combined with other antidiabetic drugs for the treatment of diabetes. Methods 180 patients with diabetes from May 2016 to December 2017 were randomly divided into two groups， combined treatment group and control group， all of which were 90 patients. The control group was treated with all kinds of other hypoglycemic drugs， and the combined treatment group was combined with acarbose（Yu Mei） on this basis. 3 days before meals， oral 50-100 mg treatment was used to observe and compare the clinical hypoglycemic effect of two groups of diabetic patients. Results After treatment， the fasting blood glucose and postprandial 2h blood sugar of the two groups were significantly lower than those before the treatment， but the effect of the combined treatment group was better than that of the control group after the treatment， and the difference level was statistically significant（P<0.05）. Moreover， during hypoglycemic treatment， the incidence of hypoglycemia and drug dosage in the combined treatment group were significantly lower than those in the control group， with statistical significance（P<0.05）. Conclusion Acarbose combined with other hypoglycemic drugs is more effective in the treatment of diabetes. It can obviously shorten the time of blood sugar in diabetic patients， effectively reduce the hypoglycemia events in the period of treatment， and reduce the actual dosage of the related drugs， which has a higher drug safety. It is worth further study of the drug in the clinic. Combined application and therapeutic effect.

[Key words] Acarbose；Hypoglycemic drugs；Diabetes

阿卡波糖是一种新型口服α-糖苷酶抑制剂[1-2]，通过高效抑制小肠上皮对碳水化合物的吸收作用，从而显著降低具体的餐后血糖水平，并促进血糖波动幅度的减小。然而随着糖尿病患者病程及病情的持续发展，单独应用阿卡波糖治疗已不能满足临床对血糖控制水平的预期，因此需要联合其他降糖药物进行降糖治疗，常用的降糖药物种类有：二甲双胍、胰岛素促泌剂、DPP-4i（二肽基肽酶-4抑制剂）、GLP-1（胰升血糖素样肽-1）受体激动剂、胰岛素制剂等[3-4]，以实现协同合理控制血糖水平的临床效果。现该文以2016年5月—2017年12月收治的180例糖尿病患者为例，对其进行随机分组，为对照组患者每日睡前给予其他降糖药物治疗，而联合治疗组则在此基础上联合给予阿卡波糖（于每日三餐前口服50～100 mg）治疗，探讨观察阿卡波糖联合其他降糖药物治疗糖尿病的临床疗效，正文具体如下。……