吴国霞 杨秀娟 邓毅 陈晖 杨延泽 杨志军

摘要：目的 以当归及其不同药用部位中5个质量指标为依据，建立基于灰色关联度模型的当归及其不同药用部位的质量评价模式。方法 根据2015年版《中华人民共和国药典》通则项下规定对当归及其不同药用部位的理化检识项目进行测定，采用HPLC及分光光度法分别测定阿魏酸及当归多糖含量。结果 当归及其不同药用部位样品的相对关联度介于0.435～0.576且比较集中，其中，全当归相对关联度为0.505，当归尾相对关联度为0.576，略高于当归身和当归头样品。结论 基于多指标测定的灰色关联度分析可系统、全面比较当归及其不同药用部位的质量，为当归药用资源的高效合理利用及药用新资源的开发提供依据。

关键词：当归；药用部位；灰色关联度；质量评价

DOI：10.3969/j.issn.1005-5304.2018.05.017

中图分类号：R284.1 文献标识码：A 文章编号：1005-5304（2018）05-0077-05

Study on Quality Evaluation of Angelicae Sinensis Radix and Its Different Medicinal Parts Based on Gray Relational Analysis

WU Guo-xia1， YANG Xiu-juan1， DENG Yi1，2， CHEN Hui1， YANG Yan-ze1， YANG Zhi-jun1，2

1. College of Pharmacy， Gansu University of Chinese Medicine， Lanzhou 730000， China； 2. Key Laboratory of Chemical and Quality Research for Traditional Chinese and Tibetan Medicines of Gansu Province， Lanzhou 730000， China

Abstract： Objective To establish the method of quality evaluation of different medicinal parts of Angelicae Sinensis Radix based on gray relational analysis on the basis of five quality indexes of Angelicae Sinensis Radix and its different medicinal parts. Methods According to the provisions of general rules of the People's Republic of China Pharmacopoeia 2015， the physicochemical identification items of Angelicae Sinensis Radix and its different medicinal parts were determined. The contents of ferulic acid and angelica polysaccharides were determined by HPLC and UV-Vis spectrophotometry. Results The relative degree of the samples of Angelicae Sinensis Radix and its different medicinal parts ranged from 0.435 to 0.576. The relative degree of Angelicae Sinensis Radix was 0.505， and the relative degree of tail part was 0.576， which was slightly higher than body and head parts. Conclusion The gray relational analysis based on the multi-index determination can systematically and comprehensively compare the quality of Angelicae Sinensis Radix and its different medicinal parts， and can provide the basis for the efficient use of medicinal resources and the development of new medicinal resources.

Keywords： Angelicae Sinensis Radix； different medicinal parts； gray relational analysis； quality evaluation

当归为伞形科植物当归Angelica sinensis（Oliv.）Diels的根，始载于《神农本草经》，被列为中品，素有“十方九歸”的美誉，主产于甘肃，尤以甘肃岷县所产品质最优、疗效最佳、产量最高。当归有补血活血、调经止痛、润肠通便的功效，主要用于血虚萎黄、

基金项目：国家自然科学基金地区基金（81360633）；甘肃省自然科学基金（1506RJZA044）；甘肃省中医药管理局科研课题（GZK-2016-25）

通讯作者：邓毅，E-mail：dengyi@gszy.edu.cn

眩晕心悸、月经不调、经闭痛经、肠燥便秘等症[1]。我国历代医家在长期临床实践中得出“当归……头能破血，身能养血，尾能行血，用者不分，不如不使”（《汤液本草》）、“当归头，止血而上行；身养血而中守；梢破血而下流；全活血而不走”（《药性赋》）等药性理论[2]，以当归身养血补血、当归尾行血破血为功效的相关方剂收载也多见于各类典籍。