刘沧海 肖汇琼

[摘要]目的 研究布洛芬混悬液治疗小儿发热的效果及安全性。方法 选取2017年2～7月我院收治的100例发热患儿，采用随机数字法分为对照组和观察组，每组50例。对照组采用金莲清热颗粒治疗，观察组采用布洛芬混悬液。比较治疗总有效率、退热时间、不良反应及治疗前后睡眠质量、生活质量评分。结果 观察组临床治疗总有效率高于对照组，差异有统计学意义（P<0.05）；观察组患者退热时间[（1.02±0.25）h]短于对照组[（3.54±0.54）h]，差异有统计学意义（t=29.945，P=0.000）；观察组患者不良反应总发生率低于对照组，差异有统计学意义（P<0.05）。治疗前，两组患者睡眠质量评分及生活质量评分的比较，差异无统计学意义（P>0.05），治疗后，观察组睡眠质量及生活质量评分均优于对照组，差异有统计学意义（P<0.05）。结论 在小儿发热治疗中给予布洛芬混悬液具有显著效果，可缩短退热时间，保证患儿睡眠质量及生活质量，值得临床推广。

[关键词]发热；布洛芬混悬液；金莲清热颗粒

[中图分类号] R725 [文献标识码] A [文章编号] 1674-4721（2018）4（a）-0121-03

Effect and safety analysis of Ibuprofen Suspension in treating pediatric fever

LIU Chang-hai1 XIAO Hui-qiong2

1.NICU，Xinguo County People′s Hospital in Ganzhou City of Jiangxi Province，Xingguo 342400，China；2.Hemodialysis Room，Xinguo County People′s Hospital in Ganzhou City of Jiangxi Province，Xingguo 342400，China

[Abstract]Objective To study the efficacy and safety of Ibuprofen Suspension in the treatment of fever in children.Methods From February to July 2017，100 children with fever treated in our hospital were randomly divided into control group and observation group，50 cases in each group.The control group was treated with Jinlian Qingre Granules，while the observation group was treated with Ibuprofen Suspension.The total effective rate，antipyretic time，adverse reactions，sleep quality and quality of life before and after treatment were compared.Results The total effective rate of the observation group was higher than that of the control group（P<0.05）.The antipyretic time （[1.02±0.25] h） in the observation group was shorter than that in the control group （[3.54±0.54] h），the difference was statistically significant （t=29.945，P=0.000）. The total incidence of adverse reactions in the observation group was lower than that in the control group（P<0.05）.Before treatment，there was no significant difference in sleep quality score and quality of life score between the two groups （P>0.05）.After treatment，the scores of sleep quality and quality of life in the observation group were better than those in the control group（P<0.05）.Conclusion The Ibuprofen Suspension has a significant effect in the treatment of pediatric fever，and can shorten the time of abating fever and ensure the sleep quality and quality of life in children，which deserves clinical promotion.

[Key words]Fever；Ibuprofen Suspension；Jinlian Qingre Granules

小兒发热是临床儿科常见病，是指体温超过正常范围，正常小儿腋下温度为36～37℃，患儿则在37℃以上。据了解[1]，小儿体温可因性别、年龄、外界环境、饮食、气温及衣服薄厚的不同而在一定正常范围内波动，体温又升高时并不一定表示小儿有病理意义，而是应该在发热的同时对小儿神态及行为举止进行观察。临床发热有短期发热和长期发热两种，短期多由感染引起，发热时间往往<2周；长期发热则多为呼吸系统感染、全身性感染、疾病、部分组织坏死等引起，发热时间往往≥2周。如发热不严重时并不会对患儿造成影响，而发热严重时，则会威胁到患儿的中枢神经系统，影响其自身健康[2]。本研究对100例发热患儿采用布洛芬混悬液治疗取得满意效果，现报道如下。

1 资料与方法

1.1 一般资料

选取2017年2～7月我院收治的100例发热患儿，采用随机数字法分为对照组和观察组，每组50例。……