徐小秀

[摘要]目的 探討雌二醇屈螺酮片联合坤泰胶囊治疗绝经期综合征的效果。方法 选取2016年1月～2017年1月我院收治的124例绝经期综合征患者作为研究对象，按照随机原则将其分为两组，每组各62例。对照组患者采用雌二醇屈螺酮片治疗，研究组患者采用雌二醇屈螺酮片联合坤泰胶囊治疗。比较两组患者治疗前后的总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、骨密度、子宫内膜厚度及改良Kupperman评分变化情况。结果 就诊时，两组患者的改良Kupperman评分、子宫内膜厚度比较，差异无统计学意义（P>0.05）。治疗后3个月，研究组患者的改良Kupperman评分低于就诊时及对照组，差异有统计学意义（P<0.05），但两组患者的子宫内膜厚度比较，差异无统计学意义（P>0.05）。研究组患者的脊椎、股骨颈骨密度均高于对照组，差异有统计学意义（P<0.05）。研究组患者的TG、HDL-C高于对照组，TC低于对照组，差异均有统计学意义（P<0.05）。结论 绝经期综合征患者采用雌二醇屈螺酮片联合坤泰胶囊治疗，效果更为理想，值得推广应用。

[关键词]绝经期综合征；雌二醇屈螺酮片；坤泰胶囊

[中图分类号] R711.75 [文献标识码] A [文章编号] 1674-4721（2018）2（b）-0120-04

Study on the effect of Estradiol and Drospirenone Tablets combined with Kuntai Capsules in the treatment of menopausal syndrome

XU Xiao-xiu

Department of Gynecology and Obstetrics，the First People′s Hospital of Linchuan District，Fuzhou，Jiangxi，China 344100

[Abstract]Objective To investigate the effect of Estradiol and Drospirenone Tablets combined with Kuntai Capsules in the treatment of menopausal syndrome.Methods A total of 124 patients with menopausal syndrome treated in our hospital from January 2016 to January 2017 were selected as subjects and they were divided into two groups according to the random principle，each with 62 cases.The patients in the control group were treated with Estradiol and Drospirenone Tablets，and the patients in the study group were treated with Estradiol and Drospirenone Tablets combined with Kuntai Capsules.The changes of total cholesterol （TC），triglyceride （TG），high-density lipoprotein （HDL-C），bone density，endometrial thickness and modified Kupperman score were compared between the two groups before and after treatment.Results At the time of diagnosis，the improved Kupperman score and the thickness of endometrium were not statistically significant in both groups （P>0.05）.3 months after treatment，the improved Kupperman score in the study group was lower than that in the control group，and the difference was statistically significant （P<0.05），while there was no significant difference in endometrial thickness between the two groups （P>0.05）.The density of spine，femoral bone and cervical bone in the study group were higher than those in the control group，and the differences were statistically significant （P<0.05）.The TG and HDL-C in the study group were higher than that in the control group，and TC was lower than the control group，and the difference was statistically significant （P<0.05）.Conclusion The effect Estradiol and Drospirenone tablets combined with Kuntai Capsules in the treatment of menopausal syndrome is more favorable，which is worthy of promotion and application.

[Key words]Menopausal syndrome；Estradiol and Drospirenone Tablets；Kuntai Capsules

绝经期综合征在临床上较为常见，主要是指妇女在绝经前后，受卵巢衰退等因素影响，而出现的一组自主神经系统功能紊乱症候群，且多数患者伴有明显神经心理症状[1-2]。绝经期综合征的发病机制较为复杂，考虑与下丘脑-垂体-卵巢-性腺轴系统的异常等因素有关[3]。当前，临床上多采用西医激素补充疗法治疗，能对临床症状进行缓解，但长期应用可诱发较多不良反应，且会导致乳腺癌发生风险提升[4]。中医认为，该病主要病因病机为天癸衰少、肾气不足，治疗原则为补肾气、调节阴阳平衡[5]。本研究选取我院收治的124例绝经期综合征患者作为研究对象，探讨雌二醇屈螺酮片联合坤泰胶囊的治疗效果，现报道如下。