林保光　王永才　宋伟　孙大鹏

【摘要】 目的 探究晚期非小细胞肺癌患者应用伽马刀联合复方红豆杉胶囊的治疗效果。方法 60例晚期非小细胞肺癌患者作为研究对象， 采取随机数字表法将患者分为观察组与对照组， 各30例。对照组患者接受伽马刀治疗， 观察组患者进行伽马刀联合复方红豆杉胶囊治疗。对比两组患者的疗效、不良反应、生活质量， 随访2年， 观察两组患者的生存率。结果 观察组患者治疗总有效率为96.67%， 高于对照组的80.00%， 差异具有统计学意义 （P<0.05）。观察组患者的不良反应率与对照组比较， 差异均无统计学意义（P>0.05）。观察组患者生活质量评分均高于对照组， 差异均具有统计学意义 （P<0.05）。观察组患者2年生存率为100.00%， 高于对照组的86.67%， 差异具有统计学意义 （P<0.05）。结论 晚期非小细胞肺癌患者应用伽马刀联合复方红豆杉胶囊的治疗效果良好， 患者2年生存率高， 生活质量佳， 值得推广应用。

【关键词】 晚期非小细胞肺癌；伽马刀；复方红豆杉胶囊；2年生存率

DOI：10.14163/j.cnki.11-5547/r.2017.30.002

Study on treatment effect of advanced non-small cell lung cancer patients treated with gamma knife combined with compound Hongdoushan capsules LIN Bao-guang， WANG Yong-cai， SONG Wei， et al. Department of Radiotherapy， Chinese Peoples Liberation Army 202 Hospital， Shenyang 110000， China

【Abstract】 Objective To investigate the treatment effect of advanced non-small cell lung cancer patients treated with gamma knife combined with compound Hongdoushan capsules. Methods A total of 60 advanced non-small cell lung cancer patients as study subjects were divided by random number table method into observation group and control group， with 30 cases in each group. The control group was treated with gamma knife， and the observation group was treated with gamma knife and compound Hongdoushan capsules. Comparison were made on efficacy， adverse reactions， quality of life between two groups， and 2 year survival rate in two groups was observed. Results The observation group had higher total treatment effective rate as 96.67% than 80.00% in the control group， and the difference was statistically significant （P<0.05）. The observation group had no statistically significant difference in incidence of adverse reactions comparing with the control group （P>0.05）. The observation group had higher quality of life score than the control group， and the difference was statistically significant （P<0.05）. The observation group had higher 2 year survival rate as 100.00% than 86.67% in the control group， and the difference was statistically significant （P<0.05）. Conclusion Combination of gamma knife and compound Hongdoushan capsules provides excellent treatment effect for advanced non-small cell lung cancer patients， with higher 2 year survival rate and better quality of life. It is worthy of promotion and application.

【Key words】 Advanced non-small cell lung cancer； Gamma knife； Compound Hongdoushan capsules；

2 year survival rate

近年， 肺癌發病率及死亡率逐年上升， 而非小细胞肺癌发病率占肺癌80.00%， 严重影响患者健康及生命安全， 引起临床高度重视[1]。研究显示， 肺癌发病与患者吸烟、饮酒、环境及工作等因素相关[2]。目前临床治疗肺癌手段较多， 包括手术治疗、放化疗、生物免疫治疗、介入治疗及中医药治疗等。早期非小细胞肺癌采取手术治疗疗效显著， 但非小细胞肺癌患者多数确诊时已发展为晚期， 且患者年龄多数较大， 体质较弱合并较大其他疾病， 故而多数患者不能接受手术治疗， 患者预后较差。有研究发现[3]， 复方红豆杉胶囊在老年晚期非小细胞肺癌中具有较好应用效果， 联合化疗治疗使得疗效大幅度增强， 引起临床关注。随着医疗技术发展， 伽马刀治疗晚期非小细胞肺癌受到人们的重视， 该方法对癌细胞具有较好抑制作用， 治疗效果良好。……