李晔

[摘要] 目的 探讨依那普利联合人胰岛素治疗糖尿病肾病的临床效果，为以后的研究提供参考。方法 随机选择该院 2015年 2月—2017年2月收治的早期糖尿病肾病330例，将所有患者平均两组分为观察组和对照组两组，对于对照组患者，该院给予常规治疗措施，对于观察组患者，除给予患者常规治疗措施外，给予患者依那普利联合人胰岛素结合治疗，所有患者均治疗6周，治疗结束后，将两组患者的临床疗效和观察指标进行对比分析。结果 治疗结束后，观察组恢复情况良好，治疗的总有效率（97.6%）明显高于对照组（83.0%），差异有统计学意义（P<0.05）。两组患者的 24 h 尿蛋白排泄率和治療前相比有明显的降低，但是观察组的降低量更高，差异有统计学意义（P<0.05）；两组患者的HbA1c、PBG、FBG结果都明显降低，但观察组的下降程度更大，差异有统计学意义（P<0.05）。 结论 给予糖尿病肾病患者依那普利结合人胰岛素治疗，治疗结果良好，有助于患者恢复健康，值得临床使用。

[关键词] 依那普利联合人胰岛素；糖尿病肾病；疗效观察

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）05（b）-0007-02

[Abstracts] Objective This paper tries to investigate the clinical effect of enalapril combined with human insulin in the treatment of diabetic nephropathy， and to provide reference for future research. Methods 330 cases of early diabetic nephropathy received in this hospital from February 2015 to February 2017 were selected and equally divided into the observation group and the control group. Patients in the control group received routine treatment， patients in the observation group added the combined treatment with enalapril and human insulin， all patients were treated for 6 weeks， and then the clinical curative effect and observation index of the two groups of patients after treatment were analyzed. Results The recovery of the observation group after the treatment was good， the total effective rate was 97.6%， significantly higher than that of the control group of 83.0%， and the difference was significant（P<0.05）. The 24 hours urinary protein excretion rate after treatment of the two groups significantly decreased compared with that before treatment， while that of the observation group decreased more significantly than the control group， and the difference was significant（P<0.05）； HbA1c， PBG and FBG of two groups significantly decreased， but the observation group decreased more obviously， and the difference was significant （P<0.05）. Conclusion The treatment of enalapril combined with human insulin in patients with diabetic nephropathy is much better， which helps patients to recover， and it is worthy of clinical use.

[Key words] Enalapril combined with human insulin； Diabetic nephropathy； Curative effect observation

糖尿病是临床工作中常见的疾病之一，人群中发病率高。由于糖尿病患者肾小球灌注不足、基底膜增厚以及脂质沉淀等问题，越来越多的糖尿病患者发生糖尿病肾病[1]。糖尿病肾病是糖尿病患者最易出现的并发症，临床症状为蛋白尿、肾小球滤过率低于正常水平，且病情越严重，患者的肾功能越异常，甚至导致肾衰竭，严重影响患者的正常生活，因此，给予患者及时有效的治疗是十分重要的[2]。该文选取2015年2月—2017年2月收治的330例患者为研究对象，研究的重点就是依那普利结合人胰岛素治疗糖尿病肾病的慢阻肺合并肺真菌病的治疗效果，为进一步的研究提供基础，现报道如下。

1 资料与方法endprint

1.1 一般资料

该文所选取该院进行治疗的330例早期糖尿病肾病患者，所有患者经血糖和尿常规检查，检查结果均符合早期糖尿病肾病的诊断标准，确诊患有早期糖尿病肾病。……