林俊宇

[摘要] 目的 研究客家人群中肥胖性高血压患者的血尿酸水平与RAS系统、胰岛素抵抗的相关性。 方法 以本院2015年1月～2016年6月间收治的120例客家高血压患者作为研究对象，根据体质量（BMI）指数将患者划分为肥胖组与普通组；对比两組患者的RAS系统组分指标、胰岛素抵抗指标以及血尿酸水平；根据血尿酸表达水平将肥胖组患者分为高表达组、中表达组与低表达组，对比两组患者的RAS系统组分指标、胰岛素抵抗指标；分析血尿酸表达水平与RAS系统组分指标、胰岛素抵抗指数的相关性。 结果 肥胖组患者的血压、BMI及腰臀比均高于普通组（P<0.05）。肥胖组血尿酸、PRA、AGT、AngⅡ、HOMA-IR均高于普通组（P<0.01）。肥胖组中高表达组、中表达组与低表达组三组间PRA、AGT、AngⅡ、HOMA-IR均可见差异（P<0.05）。血尿酸水平与PRA、AGT、AngⅡ、HOMA-IR均可见正相关性，0

[关键词] 客家人；肥胖性高血压；RAS系统；胰岛素抵抗；血尿酸

[中图分类号] R544.1；R589.2 [文献标识码] A [文章编号] 2095-0616（2017）12-136-04

Correlation of Serum Uric Acid Level and RAS System and Insulin Resistance of Patients with Obesity Hypertension in Hakka People

LIN Junyu

Department of Cardiovascular Internal Medicine，the Third Peoples Hospital of Huizhou，Huizhou 516001，China

[Abstract] Objective To study the correlation of serum uric acid level and RAS system and insulin resistance of patients with obesity hypertension in Hakka people. Methods 120 patients with hypertension in Hakka who were admitted to our hospital from January 2015 to June 2016 were selected as research objects. According to body mass index （BMI），patients were divided into the obesity group and the normal group.RAS system component index，insulin resistance index and serum urine acid level of patients in two groups were compared.According to expression level serum urine acid，obese patients were divided into the high expression group，moderate expression group and low expression group.RAS system component index and insulin resistance index of patients in two groups were compared.Correlation of expression level of serum uric acid，RAS system component index and insulin resistance index was analyzed. Results Blood pressure，BMI and waist-hip ratio of patients in the obesity group were all higher than those of the normal group （P<0.05）.Serum uric acid level，PRA，AGT，AngⅡ，HOMA-IR of the obesity group were all higher than those of the normal group（P<0.01）.Serum uric acid level，PRA，AGT，AngⅡ，HOMA-IR of high expression group，moderate expression group and low expression group in the obesity group all had differences （P<0.05）.Serum uric acid level was positively related to PRA，AGT，AngⅡ，HOMA-IR，0

[Key words] Hakka people；Obesity hypertension；RAS system；Insulin resistance；Serum uric acid

汉族是我国最大的民族，客家民系是漢族的一个分支，是汉族人向南方及海外流动的一个主要民

系，随着我国全民收入水平的大幅提高，在全国范围内肥胖的发生率均显著提高，客家人群的肥胖发生率也呈现出逐渐上升的趋势，客家人的饮食以“肥、咸、熟”为主要特色，分析这一习惯与肥胖性高血压的形成具有一定相关性。肥胖与高血压、高血脂以及高血糖等多项疾病或症状均具有密切关系[1-3]。肥胖是高血压疾病形成及进展的一项危险因素。肥胖性高血压的致病机制较为复杂，目前临床上未能完全明确。在肥胖性高血压患者中高尿酸血症、心血管系统疾病的发生率显著高于非肥胖性高血压患者。临床上公认为肥胖性高血压患者的血尿酸水平过高可能与肾素-血管紧张素-醛固酮（RAS）系统的激活、胰岛素抵抗、交感神经的张力升高、血管内皮功能与脂代谢功能紊乱等机制具有一定关系。……