李龙+魏威+于洋

[摘要] 目的 探討鼠神经生长因子联合依达拉奉治疗急性脑梗死的疗效。方法 选取2012年1月～2015年3月于我院接受治疗的80例急性脑梗死患者为研究对象，按照随机数表将患者平均分为两组，实验组和对照组每组40例。对照组患者实施常规的急性脑梗死治疗方案，实验组在此基础上加以鼠神经生长因子联合依达拉奉治疗。比较两组患者治疗疗效；统计并比较两组患者神经功能缺损评分（NIHSS）、简易智能神经状态检测评分（MMSE）；统计并比较两组患者Barther日常生活能力指数、改良式肢体运动功能量表（FMA）；检测并比较两组患者血清神经元特异性烯醇化酶（NSE）、血清超敏-C反应蛋白（hs-CRP）、血清S100β蛋白、脑源性神经因子（BDNF）、胰岛素样生长因子（IGF-1）以及白细胞介素33（IL-33）的含量。结果 实验组患者总体有效37例（92.5%），对照组总体有效30例（75.0%），两组比较具有统计学意义（P<0.05）；治疗后实验组NIHSS、MMSE、Barther日常生活功能指数以及FMA得分均高于对照组；实验组血清NSE、hs-CRP、血清S100β蛋白、脑源性神经因子、胰岛素样生长因子、白细胞介素33与对照组比较，差异具有统计学意义（P<0.05）。结论 鼠神经生长因子联合依达拉奉能够有效提高急性脑梗死的治疗效果，值得广泛推广使用。

[关键词] 鼠神经生长因子；依达拉奉；联合治疗；急性脑梗死

[中图分类号] R743.3 [文献标识码] A [文章编号] 2095-0616（2017）06-31-04

[Abstract] Objective To explore the effect of mouse nerve growth factor combined with edaravone in treatment of acute cerebral infarction. Methods 80 patients with acute cerebral infarction in our hospital from January 2012 to March 2015 were selected. According to the random number table， the patients were divided into two groups， experimental group and control group with 40 cases in each group. Patients in control group were treated with conventional treatment of acute cerebral infarction scheme， on the basis of this， patients in experimental group were treated with mouse nerve growth factor combined with edaravone treatment. Thecurative effect of two groups of patients were compared. Two groups of patients with neurologic impairment scores （NIHSS） and the simple intelligent neural state test scores （MMSE） were compared. Barther daily life ability index， modified body movement function scale （FMA） of the two groups were compared. The content of two groups of serumneur on specific enolase （NSE）， serum high sensitive C-reactive protein （hs-CRP）， serum levels of S-100β protein， brain-derived neurotrophic factor （BDNF）， insulin-like growth factor （IGF-1） and interleukin33 （IL-33） were detected and compared. Results There were 37 cases （92.5%） in the experimental group and 30 cases （75.0%） in the control group overall effectiveness. The data of the two groups were statistically different （P<0.05）. After treatment， the NIHSS， MMSE and Barther daily life function index and FMA scores were higher than those in the control group. The serum NSE， hs-CRP， serum S100β protein， brain-derived neurological factor， insulin-like growth factor and interleukin 33 in the experimental group were statistically different from those in the control group （P<0.05）. Conclusion Mouse nerve growth factor combined with edaravone can effectively improve the treatment effect of acute cerebral infarction. It is worthy of promotion.

[Key words] Mouse nerve growth factor； Edaravone； Combined therapy； Acute cerebral infarction

急性脑梗死是临床常见且多发于老年人的一

种内科急危病症，发病机制是由于脑组织供血动脉粥样硬化引发局部供血、动脉血流减少或停止，进而引起脑组织缺血、缺氧，造成脑组织软化或缺血性坏死[1-2]。发病者常伴有语言、肢体以及认知功能等障碍，该病致残率高且容易复发，术后恢复缓慢，大大增加了患者的死亡率[3-4]。据报道，脑血管疾病已经成为我国城市和农村人口致残致死原因中最主要的原因之一，而在众多脑血管病患者中，高达70%为急性脑梗死[5]。……