覃花桃+王宁莉+梁秋叶

【摘要】目的观察采用四黄水蜜外敷+秋水仙碱内服方法治疗急性痛风性关节炎的临床疗效，为急性痛风性关节炎患者提供新的治疗途径。

方法将80例急性痛风性关节炎患者随机分为两组，观察组予四黄水蜜外敷+秋水仙碱内服治疗，对照组予口服秋水仙碱治疗。评估两组患者生存质量，观察24小时两组临床症状积分和治疗3天后临床疗效。

结果治疗后两组各生存质量因子评分较治疗前均明显提高（P<0.05），治疗后24小时观察组患者的临床症状积分与对照组比较差异有统计学意义（P<0.05），治疗3天后两组秋水仙碱口服用药量及不良反应、临床效果、满意度的比较差异有统计学意义（P<0.05）。

结论采用四黄水蜜外敷+内服秋水仙碱治疗急性痛风性关节炎，可明显缩短患者发作期关节疼痛肿胀缓解时间，改善关节功能的作用，减少吃药止痛剂量及毒副作用，明显改善病人的生活质量，值得临床推广应用。

【关键词】急性痛风性关节炎；四黄水蜜；秋水仙碱

中图分类号：R593.210.47文献标识码：ADOI：10.3969/j.issn.10031383.2017.02.011

【Abstract】ObjectiveTo observe the clinical curative effect of four yellow honey for external application+colchicine for oral administration in the treatment of acute gouty arthritis，so as to provide basis for a new therapeutic approach for patients with acute gouty arthritis.

Methods80 cases of acute gouty arthritis were randomly divided into two groups，observation group were given four yellow honey for external application+colchicine for oral administration，and control group were given colchicine for oral administration only.And then，the quality of life of the two groups were evaluated，and clinical symptom score 24 hours after treatment and clinical efficacy after 3 days of treatment were observed.

ResultsAfter treatment，the quality of life scores of the two groups were significantly higher than those before treatment（P<0.05）.24 hours after treatment，difference of clinical symptom score between the two groups was statistically significant（P<0.05）.3 days after treatment，there was statistically significant difference in dosage，adverse reactions，clinical effects and satisfaction of colchicine for oral administration between the two groups（P<0.05）.

ConclusionFour yellow honey for external application+colchicine for oral administration in the treatment of acute gouty arthritis can obviously joint pain and swelling time，improve joint function，reduce dosage and side effects，and improve the quality of life of the patients.Thus，it is worthy of clinical application.

【Key words】acute gout arthritis；four yellow honey；colchicine

急性痛風性关节炎主要表现为反复发作的关节红、肿、热、痛及痛风石的形成，目前急性期常用治疗手段是内服秋水仙碱。据调查，秋水仙碱的不良反应发生率高达80%[1]，一般患者服药不到2个小时就出现一系列的胃肠道反应（恶心、呕吐、腹部绞痛、食欲减退），经常服药容易加重患者的心理负担。四黄水蜜由黄连、黄柏、大黄、黄芩、蜂蜜等组成，具有清热解毒，凉血通络，消肿止痛，缓解局部症状的功效，在治疗湿热型病症所致疼痛方面有良好疗效。……