卞丽玲+杨丰文+王媛+张莉+刘春香+张俊华+郑文科

[摘要] 该文通过系统检索相关电子数据库，收集相关文献，对蒲地蓝消炎口服液治疗小儿化脓性扁桃体炎的有效性及安全性进行系统评价。最终纳入18篇随机对照试验，涉及1 883例化脓性扁桃体炎患儿，蒲地蓝试验组957例，抗生素对照组926例。Meta结果显示：与单独应用抗生素相比，联合服用蒲地蓝可有效提高小儿化脓性扁桃体炎治疗的总有效率，缩短患儿的体温恢复正常时间，缩短扁桃体脓性分泌物消失时间，也能减少咽痛消失时间、扁桃体肿大或充血消退时间、食欲精神恢复时间。治疗期间蒲地蓝试验组均无严重不良反应。该研究表明：与单独使用抗生素相比，联合应用蒲地蓝能更有效安全地治疗小儿化脓性扁桃体炎，但由于文献研究质量偏低，上述结论有待高质量临床试验进一步验证。

[关键词] 蒲地蓝；化脓性扁桃体炎；随机对照试验；系统评价

Systematic review of effectiveness and safety of pudilan Xiaoyan oral

liquid in treating pediatric suppurative tonsilitis

BIAN Li-ling1，YANG Feng-wen1，WANG Yuan1，ZHANG Li2，LIU Chun-xiang3，ZHANG Jun-hua3，ZHENG Wen-ke3

（1. Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China；

2. Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine，Tianjin 300150，China；

3. Centre for Evidence-based Medicine Tianjin University of Traditional Chinese Medicine，Tianjin 300193，China）

[Abstract] The review aims to assess the effectiveness and safety Pudilan Xiaoyan oral liquid in treating pediatric suppurative tonsillitis systematically through searching relevant electronic database and collecting relevant literature. Meta-analysis was performed with the RevMan 5.3 software. Eighteen RCTs of 1 883 patients of pediatric suppurative tonsillitis were included. Meta-analysis showed that： compared with the application of antibiotics alone，combined with Pudilan can effectively improve the treatment of pediatric suppurative tonsillitis in efficacy rate and shorten the time of recovering normal temperature，the time of tonsil purulent discharge and can also reduce the extinction time of sore throat，antiadoncus or congestion subsided and appetite recovery. There was no severe adverse reaction during the treatment. Compared with the application of antibiotics alone，combined with Pudilan may be more effective and safe in the treatment of pediatric suppurative tonsillitis，which can not be strongly proved at present for lack of studies with high quality.

[Key words] Pudilan；suppurative tonsillitis；randomized controlled trial；systematic review

急性扁桃體炎为腭扁桃体的急性非特异性炎症，多发生于儿童和青年。急性扁桃体炎分为急性充血性扁桃体炎和急性化脓性扁桃体炎。急性化脓性扁桃体炎的主要致病菌为乙型或甲型溶血性链球菌，其他病原菌有葡萄球菌、肺炎链球菌等[1]。临床表现主要有：发病急骤，咽喉疼痛，吞咽困难，扁桃体红肿、伴有黄白色脓点等。另有头痛发热、全身不适等症状。若不及时诊治或治愈不彻底，则可引起局部或全身并发症，如肺炎、急性风湿热等。该病往往导致患儿拒食，不能吞咽而哭闹不安，影响睡眠质量。……