孙帅玲+谢雁鸣+黎元元+张寅+易丹辉+庄严

[摘要]為了解真实世界鹿瓜多肽注射液（简称鹿瓜多肽）的临床用药特征，对全国26家三级甲等医院使用鹿瓜多肽的患者（37 721例），采用Apriori算法建立模型，使用Clementine12.0进行关联分析，分析其临床中西药物联合应用特征。结果使用鹿瓜多肽的患者以45～64岁的中老年人（39.84%）居多；临床主要用于治疗骨折（17 362例，33.97%）；使用剂量最多是12 mL（41.81%）；疗程主要集中在1～3 d（28 467例，76.26%），基本符合说明书使用；临床联合中成药常与活血化瘀剂+补肾壮骨剂合用（规则支持度 19.38%），西药常与抗生素、营养类药物合用（规则支持度 39.9%）；主要中西药单独联合用药为维生素C（13 202例，35%）、金天格胶囊（7 285例，19.31%）；2种常用中西药联合用药组合分别是虎力散胶囊+金天格胶囊（规则支持度 4.458%）、苯巴比妥钠+头孢唑啉（规则支持度 10.62%）。研究显示鹿瓜多肽临床用药以中老年患者为主，临床主要用于骨折患者，临床常与活血化瘀剂、补肾壮骨剂、抗生素、营养类药物合用，有助于增强骨折的愈合，临床上使用时应注意中老年患者用药安全性及合并用药的种类及其相互作用，预防不良反应发生。

[关键词]鹿瓜多肽注射液； 用药特征； 联合用药； 真实世界研究； 医院信息系统

[Abstract]To analyze the clinical application of Cervus and Cucumis Polypeptide injection in the real world， in order to define the characteristics of clinical drug use and correlation， and provide reference for risk management and further study for Cervus and Cucumis Polypeptide injection. Descriptive analysis and association rules analysis were performed on 37 721 cases using Cervus and Cucumis Polypeptide injection in 26 hospitals nationwide. Cervus and Cucumis Polypeptide injection were mostly adopted by patients aged between 45 and 64（39.84%）； mainly used to treat fracture patients in clinic（17 362 cases， 33.97%）； 12 mL（41.81%） was the commonest dosage. And the course of treatment mainly lasted for 1-3 days（28 467 cases， 76.26%）， which was basically consistent with the description of package insert. In clinic， traditional Chinese medicines， such as blood activating and stasis removing agents and Bushen Zhuanggu agents， were frequently combined with it（rule support degree of 19.38%）. Such western medicine as antibiotics and nutritional drugs were frequently combined with it（rule support 39.9%）. The main single combined medicine were vitamin C（13 202 cases， 35%）， and Jintiange capsule（7 285 cases， 19.31%）. The commonly used combined drug pairs were Hulisan capsule and Jintiange capsule （rule support 4.458%）， phenobarbital and ceftazidime azole oxazoline（rule support degree of 10.62%）. Cervus and Cucumis Polypeptide injection is mainly adopted by elderly patients in clinic， used to treat fracture patients， and often combined with blood activating and stasis removing agents， Bushen Zhuanggu agents， antibiotics， and nutritional medicine to enhance fracture healing. In clinical application， attention shall be paid to drug safety of elderly patients and types of combined medicines and their interaction， so as to prevent adverse reactions.

[Key words]Cervus and Cucumis Polypeptide injection； drug use characteristics； combined medicine； real world； hospital information system

doi：10.4268/cjcmm20162127

鹿瓜多肽注射液（简称鹿瓜多肽）是一种复方制剂，其组分为梅花鹿Cervus nippon Temminck的骨骼和甜瓜Cucumis melo L.的干燥成熟种子，經分别提取后制成的灭菌水溶液。说明书显示本药主要用于风湿、类风湿性关节炎、强直性脊柱炎、各种类型骨折、创伤修复及腰腿疼痛等。为了解真实世界……