阳 洁，李 敏，肖秀林

·临床报告·

人工泪液治疗儿童干眼症的疗效观察

阳 洁1，李 敏2，肖秀林1

1Department of Ophthalmology，the First Affiliated Hospital of Guangxi University of Science and Technology，Liuzhou 545002，GuangxiZhuangAutonomousRegion，China；2Departmentof Ophthalmology，thePeople'sHospitalofGuangxiZhuang Autonomous Region，Nanning 530021，Guangxi Zhuang Autonomous Region，China

Correspondence to:Min Li.Department of Ophthalmology，the People's Hospital of Guangxi Zhuang Autonomous Region，Nanning 530021，Guangxi Zhuang Autonomous Region，China.limin00899 @163.com

·AIM:To observe the efficacy and safety of artificial tears for children xerophthalmia.

·METHODS:Fifty-eight cases with 116 eyes were diagnosed as xerophthalmia by tear break-up time（BUT），Schirmer|test（S|t），tear meniscus height，corneal staining，meibomian gland function test and were given artificial tears therapy for 1mo.Then the aforementioned tests were conducted again for statistical analysis.

·RESULTS:The mean BUT of all the children before treatments was 6.03±1.19s，S|t was 7.67±2.32mm/ 5min，tear meniscus height was 0.20±0.02mm，corneal staining was 1.02±0.13 scores and meibomian gland function was 2.45±0.86 scores.Sixty-two eyes in 31 cases were the lipid-deficient type，40 eyes in 20 cases were aqueous-deficient type，and 14 eyes in 7 cases wereothertypes.Accordingtotheirtypes，corresponding artificial tears therapy was given.At 1mo after treatments，the clinical symptoms were improved significantly.BUT was 13.72±1.83s，S|t was 12.38±3. 64mm/5min，tear meniscus height was 0.36±0.08mm，corneal fluorescein staining was 0.03±0.24 scores and meibomian gland function was 1.57±0.93scores. Compared with those before treatments，the difference of each observed indicators was statistically significant（P＜0.05）.No patient experienced any adverse reactions during treatments.

·CONCLUSION:Artificial tears treatment for children xerophthalmia is safe and effective.

目的：观察人工泪液治疗儿童干眼症的疗效及安全性。

方法：对58例116眼经泪膜破裂时间（tear break-up time，BUT）、泪液分泌试验（SchirmerⅠtest，SⅠt）、泪河高度、角膜荧光染色、睑板腺功能检查方法确诊为干眼症的儿童患者进行人工泪液治疗，疗程为1mo，复查时再次行上述检查，对各观察指标进行统计分析。

结果：儿童干眼症患者58例116眼治疗前BUT为6.03± 1.19s，SⅠt为7.67±2.32mm/5min，泪河高度为0.20± 0.02mm，角膜荧光染色为1.02±0.13分，睑板腺功能评分为2.45±0.86分。其中31例62眼为脂质缺乏型干眼、20例40眼为水液缺乏型干眼、7例14眼为其他类型。根据其分型，给予相应的人工泪液治疗，治疗1mo后患者的临床症状明显改善，BUT为13.72±1.83s，SⅠt为12.38±3.64mm/5min，泪河高度为0.36±0.08mm，角膜荧光染色为0.03±0.24分，睑板腺功能评分为1.57±0.93分。各观察指标与治疗前相比，差异具有统计学意义（P＜0.05）。所有患者在治疗期间均未出现任何不良反应。

结论：利用人工泪液治疗儿童干眼是安全、有效的。

儿童；干眼症；人工泪液

引用：阳洁，李敏，肖秀林.人工泪液治疗儿童干眼症的疗效观察.国际眼科杂志2016；16（3）:569-571

0　引言

干眼症是由于眼表及泪膜多因素的影响从而导致眼部干涩不适、视觉障碍的一类疾病［1］。目前，由于视频显示终端（video display terminals，VDT）的使用，干眼症已不是只发生在成年人，儿童干眼症的发病率已日趋上升［2］。此外，由于小儿挑食引起的亚临床维生素A的缺乏、宠物和玩具的亲密接触、免疫系统疾病及变态反应性疾病，亦可引起泪液质与量的异常从而导致干眼症［3］。儿童干眼症不仅影响到患儿的视觉质量，也会影响其日常生活、影响学习。……