陈菁，冯国湘*

（1.湘南学院，湖南郴州423000；2.湖南中医药大学第二附属医院，湖南长沙410005）

艾灸盒温灸对阳虚体质者症状及血清cAMP/cGMP比值的影响

陈菁1，冯国湘2*

（1.湘南学院，湖南郴州423000；2.湖南中医药大学第二附属医院，湖南长沙410005）

目的观察艾灸盒温灸疗法对阳虚体质者症状及血清环磷酸腺苷（cAMP）/环磷酸鸟苷（cGMP）比值的影响，探究阳虚体质与cAMP/cGMP比值的相关性。方法将90例阳虚体质受试者随机分为灸盒组、参附液组、肾气丸组，每组30例，3组均以7 d为1个疗程，连用4个疗程。根据治疗后受试者阳虚质判定评分量表的得分情况评价疗效，同时观察治疗前后血清cAMP/cGMP比值变化情况。结果治疗后，3组受试者阳虚体质转化分均较前显著下降（P＜0.01），灸盒组下降程度高于参附液组和肾气丸组（P＜0.05）；3组受试者血清cAMP/cGMP比值均较前下降（P＜0.05），其中灸盒组下降幅度最高（P＜0.05）；灸盒组总有效率为53.3%，参附液组总有效率为43.3%；，肾气丸组总有效率40.0%，3组整体疗效相当（P＞0.05）。结论艾灸盒温灸能显著改善阳虚体质，cAMP/cGMP与阳虚体质存在一定的相关性。

阳虚体质；温灸；艾灸盒；环磷酸腺苷；环磷酸鸟苷

〔Abstract〕Objective To observe the warming box-moxibustion′s effect on symptoms of Yang deficiency constitution and investigate its correlation with on cAMP/cGMP ratio.M ethods A total of 90 Yang deficiency constitution subjects were assigned to warming box-moxibustion group，Shenfu liquid group and Shenqi pill group，30 cases in each group，the groups were given four 7-day courses consecutively.Then the scores of yang deficiency CCMQ（Constitution in Chinese Medicine Questionnaire）were evaluated and the change of cAMP/cGMP ratio before and after treatment was observed.Results The yang deficiency CCMQ scores of the three groupswere decreased after treatment（P＜0.01）.The decrement of yang deficiency CCMQ scores in box-moxibustion group was higher than those in Shenfu liquid group and Jinkuishenqi pill group（P＜0.05）.The cAMP/cGMP ratio in serum of the three groups reduce significantly after treatment（P＜0.05）.The cAMP/cGMP ratio in box-moxibustion group has the highest extent of reducing（P＜0.05）.After treatment，the total effective rate in box-moxibustion group was 53.3%，while in Shenfu liquild group was 43.3%，and Shenqi pill group was 40.0%；while comparing the overall curative effect of the three groups，there was no statistically significant difference（P＞0.05）.Conclusion Warming box-moxibustion can significantly improve Yang deficiency constitution，and there was some correlation between cAMP/cGMP and yang deficiency constitution.

〔Keywords〕Yang-deficiency constitution；warming moxibustion；box-moxibustion；cAMP；cGMP

阳虚体质是由于人体阳气亏虚，以喜热畏寒、肢体不温等虚寒现象为主要特征的体质状态［1］，与许多疾病的发生、发展相关。现代研究认为阳虚体质可能与人体内分泌系统调节紊乱有关，有不同学者对阳虚体质与血清环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）相关性进行研究，认为cAMP、cGMP可能是阳虚体质形成的物质基础之一，证明阳虚体质者血清cAMP/cGMP比值水平异常，但其相互关系尚有争议，需要进一步研究验证。……